NECAB2 - N-terminal EF-hand calcium binding protein 2 Gene

Homo sapiens

Also known as EFCBP2; stip-2

Gene ID: 54550 | Gene type: protein coding

About NECAB2

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:83,965,177-84,002,776 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Biased expression in brain (RPKM 9.4), kidney (RPKM 3.0) and 3 other tissues.

Summary

The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]

NECAB2 Products(3)

mRNA	Protein	Name
NM_001329748.1	NP_001316677.1	N-terminal EF-hand calcium-binding protein 2 isoform 2
NM_001329749.2	NP_001316678.1	N-terminal EF-hand calcium-binding protein 2 isoform 3
NM_019065.3	NP_061938.2	N-terminal EF-hand calcium-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables A2A adenosine receptor binding	IDA IDA: Inferred from direct assay	17689978	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17689978	GOA
enables type 5 metabotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	19694902	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	17689978	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19694902	GOA
involved in positive regulation of adenosine receptor signaling pathway	IDA IDA: Inferred from direct assay	17689978	GOA
involved in positive regulation of glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	19694902	GOA
involved in positive regulation of protein localization to membrane	IDA IDA: Inferred from direct assay	19694902	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19694902	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECAB2 Protein Structure

EF-hand_7

ABM

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

N-terminal EF-hand calcium-binding protein 2

EF-hand calcium-binding protein 2

NECAB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NECAB2	Q7Z6G3	GRM5	Homo sapiens	P41594-1	Pull Down	19694902
Intra	NECAB2	Q7Z6G3	ADORA2A	Homo sapiens	P29274	Pull Down	17689978
Intra	NECAB2	Q7Z6G3	ADORA2A	Homo sapiens	P29274	Confocal	17689978

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09171	NECAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NECAB2	RGD	RGD:621844
Felis catus	NECAB2	VGNC	VGNC:63763
Mus musculus	NECAB2	MGD	MGI:2152211
Macaca mulatta	NECAB2	VGNC	VGNC:75239
Bos taurus	NECAB2	VGNC	VGNC:31978

Name
Email *

	Sorry, but the email address you supplied was invalid.