NDFIP2 - Nedd4 family interacting protein 2 Gene

Homo sapiens

Also known as N4WBP5A

Gene ID: 54602 | Gene type: protein coding

About NDFIP2

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:79,481,155-79,556,077 (from NCBI)

This gene has 30 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 31.7), skin (RPKM 21.9) and 24 other tissues.

Summary

Enables WW domain binding activity. Involved in negative regulation of gene expression; negative regulation of transport; and positive regulation of protein ubiquitination. Located in several cellular components, including Golgi apparatus; mitochondrion; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NDFIP2 Products(3)

mRNA	Protein	Name
NM_001161407.2	NP_001154879.1	NEDD4 family-interacting protein 2 isoform 2
NM_001394685.1	NP_001381614.1	NEDD4 family-interacting protein 2 isoform 3
NM_019080.3	NP_061953.2	NEDD4 family-interacting protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	12796489	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18776082	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18776082	GOA
involved in negative regulation of protein transport	IMP IMP: Inferred from mutant phenotype	18776082	GOA
involved in negative regulation of transporter activity	IMP IMP: Inferred from mutant phenotype	18776082	GOA
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	18776082	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12796489	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12796489	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12796489	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12796489	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18776082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDFIP2 Protein Structure

DUF2370

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

NEDD4 family-interacting protein 2

MAPK-activating protein PM04 PM05 PM06 PM07

Related Diseases

Diseases

Alias

Childhood Supratentorial Ependymoma

Paediatric Cerebral Ependymoma	Paediatric Supratentorial Ependymoblastoma
Paediatric Supratentorial Ependymoma	Pediatric Cerebral Ependymoma
Pediatric Supratentorial Ependymoblastoma	Pediatric Supratentorial Ependymoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09109	NDFIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NDFIP2	VGNC	VGNC:74987
Rattus norvegicus	NDFIP2	RGD	RGD:1309716
Bos taurus	NDFIP2	VGNC	VGNC:31935
Felis catus	NDFIP2	VGNC	VGNC:63751
Mus musculus	NDFIP2	MGD	MGI:1923523
Canis familiaris	NDFIP2	VGNC	VGNC:43674

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