HES2 - hes family bHLH transcription factor 2 Gene

Homo sapiens

Also known as bHLHb40

Gene ID: 54626 | Gene type: protein coding

About HES2

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,415,232-6,419,919 (from NCBI)

This gene has 6 transcripts (splice variants), 236 orthologues and 12 paralogues. Biased expression in skin (RPKM 5.8), esophagus (RPKM 4.3) and 7 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HES2 Products(1)

mRNA	Protein	Name
NM_019089.5	NP_061962.2	transcription factor HES-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES2 Protein Structure

HLH

Hairy_orange

0
100
173 a.a.

Protein Preferred Names

Protein Names

transcription factor HES-2

class B basic helix-loop-helix protein 40

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144501	D18		98.79%	Unkown
HY-144497	HE-S2		/	Unkown
HY-RS06135	HES2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HES2	VGNC	VGNC:29819
Felis catus	HES2	VGNC	VGNC:107551
Macaca mulatta	HES2	VGNC	VGNC:73174
Mus musculus	HES2	MGD	MGI:1098624
Rattus norvegicus	HES2	RGD	RGD:62082
Canis familiaris	HES2	VGNC	VGNC:41665

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