GPN2 - GPN-loop GTPase 2 Gene

Homo sapiens

Also known as ATPBD1B

Gene ID: 54707 | Gene type: protein coding

About GPN2

This gene has 5 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 6.7), duodenum (RPKM 6.2) and 25 other tissues.

Summary

Predicted to enable GTPase activity. [provided by Alliance of Genome Resources, Apr 2022]

GPN2 Products(1)

mRNA	Protein	Name
NM_018066.4	NP_060536.3	GPN-loop GTPase 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPN2 Protein Structure

ATP_bind_1

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

GPN-loop GTPase 2

ATP-binding domain 1 family member B

GPN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPN2	Q9H9Y4	GPN1	Homo sapiens	Q9HCN4	Y2H Prey Pooling	32296183
Intra	GPN2	Q9H9Y4	GPN1	Homo sapiens	Q9HCN4	Anti Tag CoIP	28514442
Intra	GPN2	Q9H9Y4	GPN1	Homo sapiens	Q9HCN4	Validated Y2H	32296183
Intra	GPN2	Q9H9Y4	GPN1	Homo sapiens	Q9HCN4	Y2H Array	32296183
Intra	GPN2	Q9H9Y4	GPN1	Homo sapiens	Q9HCN4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Lubs Type

Lubs X-Linked Mental Retardation Syndrome	Mecp2 Duplication Syndrome
Mental Retardation, X-Linked, Syndromic, Lubs Type	Mental Retardation, X-Linked, With Recurrent Respiratory Infections
Mrxsl	X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome
Mental Retardation, X-Linked Syndromic, Lubs Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05646	GPN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPN2	VGNC	VGNC:41387
Mus musculus	GPN2	MGD	MGI:2140368
Rattus norvegicus	GPN2	RGD	RGD:1311749
Macaca mulatta	GPN2	VGNC	VGNC:73010
Bos taurus	GPN2	VGNC	VGNC:29539
Felis catus	GPN2	VGNC	VGNC:62669

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