GPN1 - GPN-loop GTPase 1 Gene

Homo sapiens

Also known as XAB1; MBDIN; NTPBP; RPAP4; ATPBD1A

Gene ID: 11321 | Gene type: protein coding

About GPN1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,628,247-27,651,511 (from NCBI)

This gene has 12 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.4), thyroid (RPKM 13.8) and 25 other tissues.

Summary

This gene encodes a guanosine triphosphatase Enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GPN1 Products(4)

mRNA	Protein	Name
NM_001145047.2	NP_001138519.1	GPN-loop GTPase 1 isoform b
NM_001145048.2	NP_001138520.1	GPN-loop GTPase 1 isoform c
NM_001145049.2	NP_001138521.1	GPN-loop GTPase 1 isoform d
NM_007266.4	NP_009197.3	GPN-loop GTPase 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPN1 Protein Structure

ATP_bind_1

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

GPN-loop GTPase 1

ATP(GTP)-binding protein

Related Diseases

Diseases

Alias

Brain Sarcoma

Sarcoma Of The Brain

Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A	Xp1
Xeroderma Pigmentosum, Group A	XPA
Xeroderma Pigmentosum I	Xeroderma Pigmentosum Complementation Group A
Xp Group A	Xp, Group A
Xeroderma Pigmentosum 1	Xeroderma Pigmentosum, Type 1
XP-A

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05645	GPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPN1	VGNC	VGNC:72953
Mus musculus	GPN1	MGD	MGI:1921504
Bos taurus	GPN1	VGNC	VGNC:29538
Rattus norvegicus	GPN1	RGD	RGD:1589985
Felis catus	GPN1	VGNC	VGNC:62668

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