2. Gene
  3. OTUD4 - OTU deubiquitinase 4 Gene

OTUD4 - OTU deubiquitinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HIN1; DUBA6; HSHIN1

Gene ID: 54726 | Gene type: protein coding

About OTUD4

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:145,133,650-145,180,589 (from NCBI)

This gene has 10 transcripts (splice variants), 146 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues.

Summary

Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

OTUD4 Products(4)

mRNA Protein Name
NM_001102653.1 NP_001096123.1 OTU domain-containing protein 4 isoform 3
NM_001366057.1 NP_001352986.1 OTU domain-containing protein 4 isoform 4
NM_001366058.1 NP_001352987.1 OTU domain-containing protein 4 isoform 5
NM_017493.7 NP_059963.1 OTU domain-containing protein 4 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables K63-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
29395066 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
25944111 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA alkylation repair IDA
IDA: Inferred from direct assay
25944111 GOA
involved in negative regulation of interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
29395066 GOA
involved in negative regulation of toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
29395066 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
36943869 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
29395066 GOA
involved in regulation of protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
25944111 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD4 Protein Structure

OTU

OTU: OTU-like cysteine protease (41 - 149)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1114 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 4

HIV-1 induced protein HIN-1

OTUD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OTUD4 Q01804 STAT1 Homo sapiens P42224
Validated Y2H
25416956
Intra
OTUD4 Q01804 VDR Homo sapiens P11473-2
Y2H Array
32296183
Intra
OTUD4 Q01804 VDR Homo sapiens P11473-2
Y2H Prey Pooling
32296183
Intra
OTUD4 Q01804 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
OTUD4 Q01804 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
OTUD4 Q01804 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
OTUD4 Q01804 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
OTUD4 Q01804 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
OTUD4 Q01804 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
OTUD4 Q01804 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
OTUD4 Q01804 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
OTUD4 Q01804 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
OTUD4 Q01804 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
OTUD4 Q01804 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Boucher-Neuhauser Syndrome

Ataxia-Hypogonadism-Choroidal Dystrophy Syndrome

BNHS

Spinocerebellar Ataxia, Hypogonadotropic Hypogonadism, And Chorioretinal Dystrophy

Boucher-Neuhäuser Syndrome

Chorioretinal Dystrophy, Spinocerebellar Ataxia, And Hypogonadotropic Hypogonadism

Ataxia - Hypogonadism - Choroidal Dystrophy

Chorioretinal Dystrophy, Spinocerebellar Ataxia And Hypogonadotropic Hypogonadism

Bns

Cerebellar Ataxia With Hypogonadism And Choroidal Dystrophy Syndrome

Boucher Neuhauser Syndrome
Gordon Holmes Syndrome

Cerebellar Ataxia And Hypogonadotropic Hypogonadism

Lhrh Deficiency And Ataxia

Cerebellar Ataxia-Hypogonadism Syndrome

GDHS

Cahh

Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia

Gordon-Holmes Syndrome

Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia

Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia

Cerebellar Ataxia - Hypogonadism

Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia

Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism
Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome

NNMS

Chondrodysplasia-Disorder Of Sex Development Syndrome

Nivelon Nivelon Mabille Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161774 ST80 Inhibitor / Unkown
HY-RS09873 OTUD4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OTUD4 VGNC VGNC:75675
Mus musculus OTUD4 MGD MGI:1098801
Felis catus OTUD4 VGNC VGNC:64000
Rattus norvegicus OTUD4 RGD RGD:1305606
Bos taurus OTUD4 VGNC VGNC:32495
Canis familiaris OTUD4 VGNC VGNC:44186