2. Gene
  3. EPDR1 - ependymin related 1 Gene

EPDR1 - ependymin related 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EPDR; UCC1; MERP1; MERP-1

Gene ID: 54749 | Gene type: protein coding

About EPDR1

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:37,920,640-37,951,936 (from NCBI)

This gene has 3 transcripts (splice variants) and 489 orthologues. Broad expression in brain (RPKM 25.1), endometrium (RPKM 24.9) and 23 other tissues.

Summary

The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]

EPDR1 Products(3)

mRNA Protein Name
NM_001242946.2 NP_001229875.2 mammalian ependymin-related protein 1 isoform 2 precursor
NM_001242948.2 NP_001229877.1 mammalian ependymin-related protein 1 isoform 3
NM_017549.5 NP_060019.2 mammalian ependymin-related protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ganglioside GM1 binding IDA
IDA: Inferred from direct assay
30729188 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
30729188 GOA
enables phospholipid binding IPI
IPI: Inferred from physical interaction
30729188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in myofibroblast contraction IMP
IMP: Inferred from mutant phenotype
27245865 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
30729188 GOA
located in lysosome IDA
IDA: Inferred from direct assay
30729188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPDR1 Protein Structure

Ependymin

Ependymin: Ependymin (81 - 210)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

mammalian ependymin-related protein 1

ependymin related protein 1

Recombinant EPDR1 Proteins

Cat. No. Product Name Accession Purity
HY-P70935 EPDR1 Protein, Human (HEK293, His) Q9UM22-1 (A38-S223) ≥95%

Related Diseases

Diseases Alias
Primary Angle-Closure Glaucoma

Primary Angle Closure Glaucoma

Angle Closure Glaucoma

Acg - [Angle Closure Glaucoma]

Angle-Closure Glaucoma

Closed Angle Glaucoma

Acute Glaucoma

Prodromal Angle Closure Glaucoma
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04421 EPDR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EPDR1 MGD MGI:2145369
Bos taurus EPDR1 VGNC VGNC:28530
Canis familiaris EPDR1 VGNC VGNC:51868
Macaca mulatta EPDR1 VGNC VGNC:108399
Rattus norvegicus EPDR1 RGD RGD:1359161
Others EPDR1 NCBI