TNS2 - tensin 2 Gene

Homo sapiens

Also known as C1TEN; TENC1; C1-TEN

Gene ID: 23371 | Gene type: protein coding

About TNS2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,046,991-53,064,379 (from NCBI)

This gene has 20 transcripts (splice variants), 114 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 68.0), ovary (RPKM 31.0) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

TNS2 Products(3)

mRNA	Protein	Name
NM_015319.2	NP_056134.2	tensin-2 isoform 1
NM_170754.4	NP_736610.2	tensin-2 isoform 2
NM_198316.2	NP_938072.1	tensin-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	22019427	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	23401856	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16951145	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	23401856	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	23401856	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	16951145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNS2 Protein Structure

PTEN_C2

SH2

PTB

0
300
600
900
1200
1409 a.a.

Protein Preferred Names

Protein Names

tensin-2

C1 domain-containing phosphatase and tensin homolog

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 22

NPHS22	Nephrotic Syndrome Type 22
Nephrotic Syndrome 22

Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy

Epidermolysis Bullosa Simplex With Muscular Dystrophy	Md-Ebs
Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy	EBS5B
Ebsmd	Mdebs
Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex	Ebs-Md
Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy	Epidermolysa Bullosa Simplex With Muscular Dystrophy
Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy	Ebs With Muscular Dystrophy
Muscular Dystrophy With Epidermolysis Bullosa Simplex	Epidermolysa Bullosa Simplex, With Muscular Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14868	TNS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNS2	VGNC	VGNC:79199
Canis familiaris	TNS2	VGNC	VGNC:47702
Rattus norvegicus	TNS2	RGD	RGD:1310917
Bos taurus	TNS2	VGNC	VGNC:36208
Mus musculus	TNS2	MGD	MGI:2387586
Felis catus	TNS2	VGNC	VGNC:66436

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