2. Gene
  3. TRIM44 - tripartite motif containing 44 Gene

TRIM44 - tripartite motif containing 44 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AN3; MC7; DIPB; HSA249128

Gene ID: 54765 | Gene type: protein coding

About TRIM44

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,662,775-35,818,007 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 80 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM44 Products(1)

mRNA Protein Name
NM_017583.6 NP_060053.2 tripartite motif-containing protein 44
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17577209 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
23460740 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23460740 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
23460740 GOA
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26394807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM44 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (176 - 214)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 44

TRIM44 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM44 Q96DX7 PBX3 Homo sapiens Q5JS98
Validated Y2H
25416956
Intra
TRIM44 Q96DX7 TRIM10 Homo sapiens Q9UDY6-2
Validated Y2H
32296183
Intra
TRIM44 Q96DX7 TRIM69 Homo sapiens Q86WT6
Validated Y2H
25416956
Intra
TRIM44 Q96DX7 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra
TRIM44 Q96DX7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aniridia 3

AN3

Aniridia, Type 3
Isolated Aniridia
Supraglottis Neoplasm

Neoplasm Of Supraglottis

Supraglottic Tumor
Gillespie Syndrome

GLSP

Aniridia, Cerebellar Ataxia And Mental Deficiency

Aniridia Cerebellar Ataxia Mental Deficiency

Aniridia, Cerebellar Ataxia, And Mental Retardation

Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome

Aniridia-Cerebellar Ataxia-Intellectual Disability

Aniridia-Cerebellar Ataxia-Mental Deficiency

Partial Aniridia-Cerebellar Ataxia-Oligophrenia

Aniridia, Cerebellar Ataxia, And Intellectual Disability
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15048 TRIM44 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM44 VGNC VGNC:36336
Canis familiaris TRIM44 VGNC VGNC:47823
Felis catus TRIM44 VGNC VGNC:66540
Rattus norvegicus TRIM44 RGD RGD:1304877
Mus musculus TRIM44 MGD MGI:1931835
Macaca mulatta TRIM44 VGNC VGNC:79168