TRIM69 - tripartite motif containing 69 Gene

Homo sapiens

Also known as Trif; HSD34; RNF36; HSD-34

Gene ID: 140691 | Gene type: protein coding

About TRIM69

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:44,736,528-44,767,827 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 119 orthologues and 80 paralogues. Biased expression in testis (RPKM 19.8) and brain (RPKM 1.8).

Summary

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces Apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TRIM69 Products(5)

mRNA	Protein	Name
NM_001301144.2	NP_001288073.1	E3 ubiquitin-protein ligase TRIM69 isoform c
NM_001301145.2	NP_001288074.1	E3 ubiquitin-protein ligase TRIM69 isoform d
NM_001301146.2	NP_001288075.1	E3 ubiquitin-protein ligase TRIM69 isoform e
NM_080745.5	NP_542783.2	E3 ubiquitin-protein ligase TRIM69 isoform b
NM_182985.5	NP_892030.3	E3 ubiquitin-protein ligase TRIM69 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	37739411	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23131556	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to centrosome	IDA IDA: Inferred from direct assay	37739411	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in centrosome	IDA IDA: Inferred from direct assay	37739411	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23131556	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	23131556	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23131556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM69 Protein Structure

zf-C3HC4_4

PRY

SPRY

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM69

RFP-like domain-containing protein trimless

TRIM69 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM69	Q86WT6	DVL1	Homo sapiens	Q86TH3	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	DVL1	Homo sapiens	Q86TH3	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	MAGEA4	Homo sapiens	Q1RN33	Y2H Array	25416956
Intra	TRIM69	Q86WT6	ATP5MC1	Homo sapiens	P05496	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	ATP5MC1	Homo sapiens	P05496	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	ZNF483	Homo sapiens	Q6P088	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	RECK	Homo sapiens	Q6P9E2	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	RECK	Homo sapiens	Q6P9E2	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	IYD	Homo sapiens	Q6PHW0	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	IYD	Homo sapiens	Q6PHW0	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	IYD	Homo sapiens	Q6PHW0	Y2H Array	25416956
Intra	TRIM69	Q86WT6	SF3A3	Homo sapiens	Q12874	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	NEK8	Homo sapiens	Q86SG6	Y2H Array	25416956
Intra	TRIM69	Q86WT6	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	PPP1R18	Homo sapiens	Q6NYC8	Y2H Array	25416956
Intra	TRIM69	Q86WT6	PPP1R18	Homo sapiens	Q6NYC8	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	KRT17	Homo sapiens	Q04695	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	LARP1B	Homo sapiens	Q659C4	Y2H Array	25416956
Intra	TRIM69	Q86WT6	LARP1B	Homo sapiens	Q659C4	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	FKBP1B	Homo sapiens	P68106	Y2H Array	25416956
Intra	TRIM69	Q86WT6	ASNS	Homo sapiens	P08243	Y2H Array	31515488
Intra	TRIM69	Q86WT6	ASNS	Homo sapiens	P08243	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	MAGEA4	Homo sapiens	P43358	Y2H	21516116
Intra	TRIM69	Q86WT6	RSPH14	Homo sapiens	Q9UHP6	Y2H Prey Pooling	25416956
Intra	TRIM69	Q86WT6	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	25416956
Intra	TRIM69	Q86WT6	TRIM44	Homo sapiens	Q96DX7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15068	TRIM69 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM69	VGNC	VGNC:54380
Macaca mulatta	TRIM69	VGNC	VGNC:79096
Felis catus	TRIM69	VGNC	VGNC:66551
Rattus norvegicus	TRIM69	RGD	RGD:1305074
Mus musculus	TRIM69	MGD	MGI:1918178
Bos taurus	TRIM69	VGNC	VGNC:36350
Others	TRIM69	NCBI

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