2. Gene
  3. ERCC6L - ERCC excision repair 6 like, spindle assembly checkpoint helicase Gene

ERCC6L - ERCC excision repair 6 like, spindle assembly checkpoint helicase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PICH; RAD26L

Gene ID: 54821 | Gene type: protein coding

About ERCC6L

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,204,665-72,239,027 (from NCBI)

This gene has 2 transcripts (splice variants), 220 orthologues and 30 paralogues. Broad expression in lymph node (RPKM 1.5), bone marrow (RPKM 1.3) and 18 other tissues.

Summary

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]

ERCC6L Products(2)

mRNA Protein Name
NM_001009954.3 NP_001009954.1 DNA excision repair protein ERCC-6-like isoform b
NM_017669.4 NP_060139.2 DNA excision repair protein ERCC-6-like isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables DNA translocase activity IDA
IDA: Inferred from direct assay
23973328 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20360068 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERCC6L Protein Structure

SNF2_N

SNF2_N: SNF2 family N-terminal domain (99 - 416)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (495 - 574)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1250 a.a.
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-6-like

ATP-dependent helicase ERCC6-like

ERCC6L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ERCC6L Q2NKX8 LMO4 Homo sapiens P61968
Validated Y2H
25416956
Intra ERCC6L Q2NKX8 LMO4 Homo sapiens P61968
Y2H Prey Pooling
25416956
Intra ERCC6L Q2NKX8 LMO4 Homo sapiens P61968
Y2H Array
25416956
Intra ERCC6L Q2NKX8 PLK1 Homo sapiens P53350
TAP
20360068
Intra ERCC6L Q2NKX8 PLK1 Homo sapiens P53350
Anti Tag CoIP
28514442
Intra ERCC6L Q2NKX8 PLK1 Homo sapiens P53350
Anti Tag CoIP
33961781
Intra ERCC6L Q2NKX8 PLK1 Homo sapiens P53350
Anti Tag CoIP
26496610
Intra ERCC6L Q2NKX8 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra ERCC6L Q2NKX8 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra ERCC6L Q2NKX8 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04484 ERCC6L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04485 ERCC6L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ERCC6L VGNC VGNC:54138
Felis catus ERCC6L VGNC VGNC:97420
Rattus norvegicus ERCC6L RGD RGD:1565734
Mus musculus ERCC6L MGD MGI:2654144
Macaca mulatta ERCC6L VGNC VGNC:81397
Bos taurus ERCC6L VGNC VGNC:28573