2. Gene
  3. SYTL2 - synaptotagmin like 2 Gene

SYTL2 - synaptotagmin like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151

Gene ID: 54843 | Gene type: protein coding

About SYTL2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:85,694,229-85,854,870 (from NCBI)

This gene has 29 transcripts (splice variants), 199 orthologues and 31 paralogues. Broad expression in stomach (RPKM 22.4), colon (RPKM 16.3) and 17 other tissues.

Summary

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

SYTL2 Products(47)

mRNA Protein Name
NM_001162951.4 NP_001156423.1 synaptotagmin-like protein 2 isoform g
NM_001162952.3 NP_001156424.1 synaptotagmin-like protein 2 isoform h
NM_001162953.4 NP_001156425.1 synaptotagmin-like protein 2 isoform i
NM_001289608.2 NP_001276537.1 synaptotagmin-like protein 2 isoform j
NM_001289609.2 NP_001276538.1 synaptotagmin-like protein 2 isoform k
NM_001289610.2 NP_001276539.1 synaptotagmin-like protein 2 isoform h
NM_001365826.2 NP_001352755.1 synaptotagmin-like protein 2 isoform l
NM_001365827.2 NP_001352756.1 synaptotagmin-like protein 2 isoform m
NM_001365828.2 NP_001352757.1 synaptotagmin-like protein 2 isoform b
NM_001365829.2 NP_001352758.1 synaptotagmin-like protein 2 isoform b
NM_001365830.2 NP_001352759.1 synaptotagmin-like protein 2 isoform b
NM_001365831.2 NP_001352760.1 synaptotagmin-like protein 2 isoform n
NM_001365832.2 NP_001352761.1 synaptotagmin-like protein 2 isoform o
NM_001365833.2 NP_001352762.1 synaptotagmin-like protein 2 isoform f
NM_001365834.2 NP_001352763.1 synaptotagmin-like protein 2 isoform p
NM_001365835.2 NP_001352764.1 synaptotagmin-like protein 2 isoform q
NM_001394447.1 NP_001381376.1 synaptotagmin-like protein 2 isoform r
NM_001394448.1 NP_001381377.1 synaptotagmin-like protein 2 isoform s
NM_001394449.1 NP_001381378.1 synaptotagmin-like protein 2 isoform s
NM_001394450.1 NP_001381379.1 synaptotagmin-like protein 2 isoform t
NM_001394451.1 NP_001381380.1 synaptotagmin-like protein 2 isoform u
NM_001394452.1 NP_001381381.1 synaptotagmin-like protein 2 isoform v
NM_001394453.1 NP_001381382.1 synaptotagmin-like protein 2 isoform w
NM_001394454.1 NP_001381383.1 synaptotagmin-like protein 2 isoform w
NM_001394455.1 NP_001381384.1 synaptotagmin-like protein 2 isoform x
NM_001394456.1 NP_001381385.1 synaptotagmin-like protein 2 isoform x
NM_001394457.1 NP_001381386.1 synaptotagmin-like protein 2 isoform g
NM_001394458.1 NP_001381387.1 synaptotagmin-like protein 2 isoform g
NM_001394459.1 NP_001381388.1 synaptotagmin-like protein 2 isoform g
NM_001394460.1 NP_001381389.1 synaptotagmin-like protein 2 isoform y
NM_001394461.1 NP_001381390.1 synaptotagmin-like protein 2 isoform z
NM_001394462.1 NP_001381391.1 synaptotagmin-like protein 2 isoform aa
NM_001394464.1 NP_001381393.1 synaptotagmin-like protein 2 isoform bb
NM_001394465.1 NP_001381394.1 synaptotagmin-like protein 2 isoform cc
NM_001394466.1 NP_001381395.1 synaptotagmin-like protein 2 isoform dd
NM_001394467.1 NP_001381396.1 synaptotagmin-like protein 2 isoform ee
NM_001394468.1 NP_001381397.1 synaptotagmin-like protein 2 isoform ff
NM_001394469.1 NP_001381398.1 synaptotagmin-like protein 2 isoform gg
NM_001394470.1 NP_001381399.1 synaptotagmin-like protein 2 isoform hh
NM_001394471.1 NP_001381400.1 synaptotagmin-like protein 2 isoform ii
NM_001394472.1 NP_001381401.1 synaptotagmin-like protein 2 isoform ii
NM_001394473.1 NP_001381402.1 synaptotagmin-like protein 2 isoform jj
NM_032943.5 NP_116561.1 synaptotagmin-like protein 2 isoform a
NM_206927.4 NP_996810.2 synaptotagmin-like protein 2 isoform c
NM_206928.4 NP_996811.2 synaptotagmin-like protein 2 isoform d
NM_206929.4 NP_996812.1 synaptotagmin-like protein 2 isoform b
NM_206930.4 NP_996813.1 synaptotagmin-like protein 2 isoform f
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatase binding IDA
IDA: Inferred from direct assay
19389623 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IMP
IMP: Inferred from mutant phenotype
17182843 GOA
enables phosphatidylserine binding IMP
IMP: Inferred from mutant phenotype
17182843 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Biological Process GO Annotation Evidence Reference Source
involved in exocytosis IDA
IDA: Inferred from direct assay
18812475 GOA
involved in vesicle docking involved in exocytosis IDA
IDA: Inferred from direct assay
18812475 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18812475 GOA
located in exocytic vesicle IDA
IDA: Inferred from direct assay
18812475 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17182843 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYTL2 Protein Structure

FYVE_2

FYVE_2: FYVE-type zinc finger (6 - 52)

C2

C2: C2 domain (645 - 733)

C2

C2: C2 domain (795 - 879)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 934 a.a.
Protein Preferred Names Protein Names

synaptotagmin-like protein 2

breast cancer-associated antigen SGA-72M

SYTL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SYTL2 Q9HCH5 PPP1CA Homo sapiens P62136
Pull Down
19389623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Griscelli Syndrome

Chediak-Higashi-Like Syndrome

Griscelli-Prunieras Syndrome

Partial Albinism-Immunodeficiency Syndrome

Griscelli Disease

Gs

Hypopigmentation Immunodeficiency Disease

Partial Albinism With Immunodeficiency

Immunodeficiency Syndrome With Hypopigmentation

Hypopigmentation-Immunodeficiency Disease
Griscelli Syndrome, Type 2

Griscelli Syndrome Type 2

GS2

Griscelli Syndrome With Hemophagocytic Syndrome

Partial Albinism And Immunodeficiency Syndrome

Paid Syndrome

Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome

Griscelli-Prunieras Syndrome Type 2

Griscelli-Pruniéras Syndrome Type 2

Griscelli Syndrome 2
Tinea Nigra

Microsporosis Nigra

Infection By Cladosporium Werneckii

Keratomycosis Nigricans

Tinea Palmaris Nigra

Keratomycosis Nigricans Palmaris
Piebald Trait

Piebaldism

PBT

Partial Albinism

Albinoidism, Oculocutaneous, Autosomal Dominant
Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3

GS3

Griscelli-Prunieras Syndrome Type 3

Hypomelanosis With No Immunologic Or Neurologic Manifestations

Griscelli Syndrome 3
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14123 SYTL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SYTL2 VGNC VGNC:78123
Felis catus SYTL2 VGNC VGNC:81930
Rattus norvegicus SYTL2 RGD RGD:1307647
Canis familiaris SYTL2 VGNC VGNC:52293
Mus musculus SYTL2 MGD MGI:1933366