HAUS4 - HAUS augmin like complex subunit 4 Gene

Homo sapiens

Also known as C14orf94

Gene ID: 54930 | Gene type: protein coding

About HAUS4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,946,228-22,957,090 (from NCBI)

This gene has 21 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in ovary (RPKM 23.6), bone marrow (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

HAUS4 Products(3)

mRNA	Protein	Name
NM_001166269.2	NP_001159741.1	HAUS augmin-like complex subunit 4 isoform 1
NM_001166270.2	NP_001159742.1	HAUS augmin-like complex subunit 4 isoform 2
NM_017815.3	NP_060285.2	HAUS augmin-like complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS4 Protein Structure

HAUS4

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

HAUS augmin-like complex subunit 4

homologous to Augmin subunits

HAUS4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAUS4	Q9H6D7	HAUS1	Homo sapiens	Q96CS2	GMS	25173975
Intra	HAUS4	Q9H6D7	HAUS1	Homo sapiens	Q96CS2	TAP	20360068
Intra	HAUS4	Q9H6D7	HAUS6	Homo sapiens	Q7Z4H7	TAP	20360068

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Enamel Caries

Primary Dental Caries	Dental Caries Limited To Enamel
Simple Dental Cavity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06016	HAUS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HAUS4	MGD	MGI:1261794
Felis catus	HAUS4	VGNC	VGNC:104399
Rattus norvegicus	HAUS4	RGD	RGD:1305288

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