2. Gene
  3. HAUS1 - HAUS augmin like complex subunit 1 Gene

HAUS1 - HAUS augmin like complex subunit 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEIC; CCDC5; HEI-C; HsT1461

Gene ID: 115106 | Gene type: protein coding

About HAUS1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,104,385-46,128,333 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in lymph node (RPKM 14.6), bone marrow (RPKM 12.1) and 25 other tissues.

Summary

HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

HAUS1 Products(1)

mRNA Protein Name
NM_138443.4 NP_612452.1 HAUS augmin-like complex subunit 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19369198 GOA
Biological Process GO Annotation Evidence Reference Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence Reference Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 1

coiled-coil domain containing 5 (spindle associated)

HAUS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HAUS1 Q96CS2 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra HAUS1 Q96CS2 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra HAUS1 Q96CS2 ODAD1 Homo sapiens Q96M63
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 ODAD1 Homo sapiens Q96M63
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra HAUS1 Q96CS2 TFPT Homo sapiens P0C1Z6-2
Y2H Array
25416956
Intra HAUS1 Q96CS2 TFPT Homo sapiens P0C1Z6-2
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra HAUS1 Q96CS2 BORCS6 Homo sapiens Q96GS4
Validated Y2H
32296183
Intra HAUS1 Q96CS2 CAGE1 Homo sapiens Q8TC20
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CENPP Homo sapiens Q6IPU0
Y2H Prey Pooling
32296183
Intra HAUS1 Q96CS2 SYCE3 Homo sapiens A1L190
Y2H Array
31515488
Intra HAUS1 Q96CS2 CRSP9 Homo sapiens Q6IAZ5
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CRSP9 Homo sapiens Q6IAZ5
Validated Y2H
25416956
Intra HAUS1 Q96CS2 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra HAUS1 Q96CS2 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra HAUS1 Q96CS2 KRT38 Homo sapiens O76015
Validated Y2H
25416956
Intra HAUS1 Q96CS2 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra HAUS1 Q96CS2 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 FGFR1OP2 Homo sapiens Q9NVK5
Y2H Array
25416956
Intra HAUS1 Q96CS2 FGFR1OP2 Homo sapiens Q9NVK5
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 FGFR1OP2 Homo sapiens Q9NVK5
Validated Y2H
25416956
Intra HAUS1 Q96CS2 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra HAUS1 Q96CS2 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra HAUS1 Q96CS2 TRIM69 Homo sapiens Q86WT6-2
MAPPIT
32296183
Intra HAUS1 Q96CS2 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra HAUS1 Q96CS2 CDR2 Homo sapiens Q01850
Y2H Array
25416956
Intra HAUS1 Q96CS2 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra HAUS1 Q96CS2 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
GMS
25173975
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
SLC
27107012
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
DLS
25173975
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
TEM
25173975
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
SLS
25173975
Intra HAUS1 Q96CS2 HAUS4 Homo sapiens Q9H6D7
GMS
19369198
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
GMS
25173975
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
TAP
20360068
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
TEM
25173975
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
DLS
25173975
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
GMS
19369198
Intra HAUS1 Q96CS2 HAUS6 Homo sapiens Q7Z4H7
SLS
25173975
Intra HAUS1 Q96CS2 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
32296183
Intra HAUS1 Q96CS2 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra HAUS1 Q96CS2 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra HAUS1 Q96CS2 CCDC57 Homo sapiens Q2TAC2
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 C3orf62 Homo sapiens Q6ZUJ4
Y2H Array
31515488
Intra HAUS1 Q96CS2 C3orf62 Homo sapiens Q6ZUJ4
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
Intra HAUS1 Q96CS2 TXN2 Homo sapiens Q99757
Y2H Array
32296183
Intra HAUS1 Q96CS2 DMD Homo sapiens P11532
Y2H Array
25416956
Intra HAUS1 Q96CS2 KRT18 Homo sapiens P05783
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 KRT18 Homo sapiens P05783
Y2H Array
25416956
Intra HAUS1 Q96CS2 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra HAUS1 Q96CS2 TSG101 Homo sapiens Q99816
Y2H Array
25416956
Intra HAUS1 Q96CS2 NUP62 Homo sapiens P37198
Y2H Array
25416956
Intra HAUS1 Q96CS2 NUP62 Homo sapiens P37198
Validated Y2H
25416956
Intra HAUS1 Q96CS2 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra HAUS1 Q96CS2 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra HAUS1 Q96CS2 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra HAUS1 Q96CS2 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra HAUS1 Q96CS2 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra HAUS1 Q96CS2 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra HAUS1 Q96CS2 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra HAUS1 Q96CS2 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra HAUS1 Q96CS2 GSN Homo sapiens P06396
Y2H Array
32814053
Intra HAUS1 Q96CS2 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra HAUS1 Q96CS2 BLOC1S6 Homo sapiens Q9UL45
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 DTNBP1 Homo sapiens Q96EV8
Validated Y2H
25416956
Intra HAUS1 Q96CS2 DTNBP1 Homo sapiens Q96EV8
Y2H Array
25416956
Intra HAUS1 Q96CS2 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra HAUS1 Q96CS2 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra HAUS1 Q96CS2 ARFIP2 Homo sapiens P53365
Validated Y2H
25416956
Intra HAUS1 Q96CS2 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra HAUS1 Q96CS2 INCA1 Homo sapiens Q0VD86
Validated Y2H
25416956
Intra HAUS1 Q96CS2 SYCE1 Homo sapiens Q8N0S2
Y2H Array
25416956
Intra HAUS1 Q96CS2 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 KDM1A Homo sapiens O60341
Anti Tag CoIP
23455924
Intra HAUS1 Q96CS2 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
25416956
Intra HAUS1 Q96CS2 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra HAUS1 Q96CS2 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
25416956
Intra HAUS1 Q96CS2 STX11 Homo sapiens O75558
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 DCTN2 Homo sapiens Q13561
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 DCTN2 Homo sapiens Q13561
Validated Y2H
25416956
Intra HAUS1 Q96CS2 DCTN2 Homo sapiens Q13561
Y2H Array
25416956
Intra HAUS1 Q96CS2 NDC80 Homo sapiens O14777
Validated Y2H
25416956
Intra HAUS1 Q96CS2 NINL Homo sapiens Q9Y2I6
Y2H Array
25416956
Intra HAUS1 Q96CS2 NINL Homo sapiens Q9Y2I6
Validated Y2H
25416956
Intra HAUS1 Q96CS2 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra HAUS1 Q96CS2 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra HAUS1 Q96CS2 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra HAUS1 Q96CS2 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra HAUS1 Q96CS2 LDOC1 Homo sapiens O95751
Validated Y2H
25416956
Intra HAUS1 Q96CS2 LDOC1 Homo sapiens O95751
Y2H Array
25416956
Intra HAUS1 Q96CS2 NUP54 Homo sapiens Q7Z3B4
Y2H Array
25416956
Intra HAUS1 Q96CS2 NUP54 Homo sapiens Q7Z3B4
Validated Y2H
25416956
Intra HAUS1 Q96CS2 NUP54 Homo sapiens Q7Z3B4
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 LURAP1 Homo sapiens Q96LR2
Y2H Array
31515488
Intra HAUS1 Q96CS2 LURAP1 Homo sapiens Q96LR2
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra HAUS1 Q96CS2 CEP63 Homo sapiens Q96MT8
Validated Y2H
25416956
Intra HAUS1 Q96CS2 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
25416956
Intra HAUS1 Q96CS2 KRT19 Homo sapiens P08727
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CEP170P1 Homo sapiens Q96L14
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra HAUS1 Q96CS2 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 IFT20 Homo sapiens Q8IY31
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
Intra HAUS1 Q96CS2 IFIT3 Homo sapiens O14879
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 IFIT3 Homo sapiens O14879
Y2H Array
25416956
Intra HAUS1 Q96CS2 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 CEP55 Homo sapiens Q53EZ4
Y2H Array
25416956
Intra HAUS1 Q96CS2 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra HAUS1 Q96CS2 TRIM69 Homo sapiens Q86WT6
Validated Y2H
25416956
Intra HAUS1 Q96CS2 AK8 Homo sapiens Q96MA6
Validated Y2H
25416956
Intra HAUS1 Q96CS2 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
25416956
Intra HAUS1 Q96CS2 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aleukemic Leukemia Cutis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06013 HAUS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HAUS1 MGD MGI:2385076
Rattus norvegicus HAUS1 RGD RGD:619909
Canis familiaris HAUS1 VGNC VGNC:41602
Bos taurus HAUS1 VGNC VGNC:29757
Felis catus HAUS1 VGNC VGNC:62755
Macaca mulatta HAUS1 VGNC VGNC:103824