TRMT10C - tRNA methyltransferase 10C, mitochondrial RNase P subunit Gene

Homo sapiens

Also known as HNYA; MRPP1; COXPD30; RG9MTD1

Gene ID: 54931 | Gene type: protein coding

About TRMT10C

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,561,868-101,566,446 (from NCBI)

This gene has 2 transcripts (splice variants), 184 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 10.2), lymph node (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]

TRMT10C Products(1)

mRNA	Protein	Name
NM_017819.4	NP_060289.2	tRNA methyltransferase 10 homolog C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	29880640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18984158	GOA
enables tRNA (adenine(9)-N1)-methyltransferase activity	IDA IDA: Inferred from direct assay	23042678	GOA
enables tRNA (guanosine(9)-N1)-methyltransferase activity	IDA IDA: Inferred from direct assay	23042678	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	29040705	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IDA IDA: Inferred from direct assay	29072297	GOA
involved in mitochondrial RNA 5'-end processing	IMP IMP: Inferred from mutant phenotype	21593607	GOA
involved in mitochondrial tRNA 3'-end processing	IDA IDA: Inferred from direct assay	29040705	GOA
involved in mitochondrial tRNA 5'-end processing	IDA IDA: Inferred from direct assay	29040705	GOA
involved in mitochondrial tRNA methylation	IDA IDA: Inferred from direct assay	23042678	GOA
involved in mitochondrial tRNA processing	IMP IMP: Inferred from mutant phenotype	27132592	GOA
involved in positive regulation of mitochondrial translation	IMP IMP: Inferred from mutant phenotype	27132592	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	24703694	GOA
part of mitochondrial ribonuclease P complex	IPI IPI: Inferred from physical interaction	29880640	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23042678	GOA
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	27132592	GOA
part of tRNA methyltransferase complex	IPI IPI: Inferred from physical interaction	23042678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT10C Protein Structure

tRNA_m1G_MT

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

tRNA methyltransferase 10 homolog C

HBV pre-S2 trans-regulated protein 2

TRMT10C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRMT10C	Q7L0Y3	HSD17B10	Homo sapiens	Q99714	Anti Tag CoIP	18984158
Intra	TRMT10C	Q7L0Y3	PRORP	Homo sapiens	O15091	Anti Tag CoIP	18984158
Intra	TRMT10C	Q7L0Y3	HSD17B10	Homo sapiens	Q99714	Methyltransferase Ass	29880640

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 30

COXPD30	Combined Oxidative Phosphorylation Defect Type 30
Combined Oxidative Phosphorylation Deficiency, Type 30

Mitochondrial Disease

Mitochondrial Diseases

Mitochondrial Disorder

Combined Oxidative Phosphorylation Deficiency 6

Severe X-Linked Mitochondrial Encephalomyopathy	COXPD6
Mitochondrial Encephalomyopathy Due To Combined Oxidative Phosphorylation Defect 6	Mitochondrial Encephalomyopathy Due To Coxpd6
Encephalomyopathy, Mitochondrial, X-Linked	Encephalomyopathy Mitochondrial X-Linked
Oxidative Phosphorylation Deficiency, Combined, Type 6

Alpha-Aminoadipic And Alpha-Ketoadipic Aciduria

2-Aminoadipic 2-Oxoadipic Aciduria	Amoxad
AAKAD	2-Ketoadipic Aciduria
Alpha-Aminoadipic Aciduria	Amino Adipic Aciduria
Aciduria, 2-Aminoadipic 2-Oxoadipic

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Respiratory Disease	Acute And Chronic Respiratory Failure
Respiratory Insufficiency/Failure	Chronic Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15088	TRMT10C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRMT10C	RGD	RGD:1306333
Macaca mulatta	TRMT10C	VGNC	VGNC:79569
Bos taurus	TRMT10C	VGNC	VGNC:36367
Mus musculus	TRMT10C	MGD	MGI:1196261
Felis catus	TRMT10C	VGNC	VGNC:66567
Canis familiaris	TRMT10C	VGNC	VGNC:47853

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