2. Gene
  3. RNF125 - ring finger protein 125 Gene

RNF125 - ring finger protein 125 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TNORS; TRAC1; TRAC-1

Gene ID: 54941 | Gene type: protein coding

About RNF125

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,018,825-32,088,144 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a novel E3 ubiquitin Ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

RNF125 Products(1)

mRNA Protein Name
NM_017831.4 NP_060301.2 E3 ubiquitin-protein ligase RNF125
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables p53 binding IPI
IPI: Inferred from physical interaction
25591766 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17460044 GOA
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
27411375 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17460044 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
27411375 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of RIG-I signaling pathway IDA
IDA: Inferred from direct assay
17460044 GOA
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
17460044 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
27411375 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
17460044 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
17990982 GOA
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
26471729 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
17990982 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF125 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (36 - 76)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (140 - 196)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF125

T-cell RING activation protein 1

RNF125 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNF125 Q96EQ8 MAVS Homo sapiens Q7Z434-1
Anti Tag CoIP
17460044
Intra
RNF125 Q96EQ8 RIGI Homo sapiens O95786-1
Anti Bait CoIP
17460044
Intra
RNF125 Q96EQ8 RIGI Homo sapiens O95786-1
Anti Tag CoIP
17460044
Intra
RNF125 Q96EQ8 UBE2E2 Homo sapiens Q96LR5
Y2H
17460044
Intra
RNF125 Q96EQ8 UBE2E2 Homo sapiens Q96LR5
Anti Tag CoIP
17460044
Intra
RNF125 Q96EQ8 VCP Homo sapiens P55072
Pull Down
26471729
Intra
RNF125 Q96EQ8 VCP Homo sapiens P55072
Anti Bait CoIP
26471729
Intra
RNF125 Q96EQ8 IFIH1 Homo sapiens Q9BYX4
Anti Tag CoIP
17460044
Intra
RNF125 Q96EQ8 RIGI Homo sapiens O95786
Anti Bait CoIP
26471729
Intra
RNF125 Q96EQ8 RIGI Homo sapiens O95786
Pull Down
26471729
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tenorio Syndrome

TNORS

Overgrowth, Macrocephaly, And Intellectual Disability Syndrome
Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D

Hmn Iid

Dhmn2d

Distal Hereditary Motor Neuronopathy Type 2d

Distal Hereditary Motor Neuropathy Type Iid

Neuronopathy, Distal Hereditary Motor, Type 2d

Neuropathy, Distal Hereditary Motor, Type Iid

Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant

Distal Spinal Muscular Atrophy With Calf Predominance

Neuronopathy, Distal Hereditary Motor, 2d

Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant

Dhmn Iid

Neuropathy, Motor, Distal, Hereditary, Type 2d
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12044 RNF125 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF125 RGD RGD:1306757
Felis catus RNF125 VGNC VGNC:64667
Mus musculus RNF125 MGD MGI:1914914
Canis familiaris RNF125 VGNC VGNC:45627
Macaca mulatta RNF125 VGNC VGNC:104244
Bos taurus RNF125 VGNC VGNC:34017