2. Gene
  3. LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AYTL1; LPLAT9; AGPAT11; LysoPAFAT

Gene ID: 54947 | Gene type: protein coding

About LPCAT2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,509,072-55,586,666 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded Enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The Enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

LPCAT2 Products(1)

mRNA Protein Name
NM_017839.5 NP_060309.2 lysophosphatidylcholine acyltransferase 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
20363836 GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
21498505 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: Inferred from direct assay
21498505 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21498505 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
20363836 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
21498505 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT2 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (129 - 245)

EF-hand_7

EF-hand_7: EF-hand domain pair (396 - 456)

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  • 544 a.a.
Protein Preferred Names Protein Names

lysophosphatidylcholine acyltransferase 2

1-AGP acyltransferase 11

LPCAT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LPCAT2 Q7L5N7 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
LPCAT2 Q7L5N7 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
LPCAT2 Q7L5N7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
LPCAT2 Q7L5N7 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
LPCAT2 Q7L5N7 RHBDD1 Homo sapiens Q8TEB9
Validated Y2H
32296183
Intra
LPCAT2 Q7L5N7 RHBDD1 Homo sapiens Q8TEB9
Y2H Array
32296183
Intra
LPCAT2 Q7L5N7 RHBDD1 Homo sapiens Q8TEB9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multicentric Osteolysis, Nodulosis, And Arthropathy

Torg-Winchester Syndrome

Torg Syndrome

Nao Syndrome

MONA

Nodulosis-Arthropathy-Osteolysis Syndrome

Al-Aqeel Sewairi Syndrome

Hereditary Multicentric Osteolysis

Osteolysis, Hereditary Multicentric

Torg-Winchester Syndrome, Formerly

Multicentric Osteolysis Nodulosis And Arthropathy

Multicentric Osteolysis, Nodulosis And Arthropathy

Osteolysis, Multicentric, Nodulosis, And Arthropathy
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Scrotal Carcinoma

Carcinoma Of Scrotum

Malignant Neoplasm Of Scrotum

Neoplasm Of Scrotum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112825 TSI-01 98.31% Unkown
HY-RS07765 LPCAT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LPCAT2 RGD RGD:2325051
Bos taurus LPCAT2 VGNC VGNC:30962
Macaca mulatta LPCAT2 VGNC VGNC:74365
Felis catus LPCAT2 VGNC VGNC:63265
Canis familiaris LPCAT2 VGNC VGNC:42749
Mus musculus LPCAT2 MGD MGI:3606214