LPCAT2 - lysophosphatidylcholine acyltransferase 2 Gene

Homo sapiens

Also known as AYTL1; LPLAT9; AGPAT11; LysoPAFAT

Gene ID: 54947 | Gene type: protein coding

About LPCAT2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,509,072-55,586,666 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded Enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The Enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

LPCAT2 Products(1)

mRNA	Protein	Name
NM_017839.5	NP_060309.2	lysophosphatidylcholine acyltransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	20363836	GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	21498505	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	21498505	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21498505	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20363836	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	21498505	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT2 Protein Structure

Acyltransferase

EF-hand_7

0
100
200
300
400
500
544 a.a.

Protein Preferred Names

Protein Names

lysophosphatidylcholine acyltransferase 2

1-AGP acyltransferase 11

Related Diseases

Diseases

Alias

Multicentric Osteolysis, Nodulosis, And Arthropathy

Torg-Winchester Syndrome	Torg Syndrome
Nao Syndrome	MONA
Nodulosis-Arthropathy-Osteolysis Syndrome	Al-Aqeel Sewairi Syndrome
Hereditary Multicentric Osteolysis	Osteolysis, Hereditary Multicentric
Torg-Winchester Syndrome, Formerly	Multicentric Osteolysis Nodulosis And Arthropathy
Multicentric Osteolysis, Nodulosis And Arthropathy	Osteolysis, Multicentric, Nodulosis, And Arthropathy

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Scrotal Carcinoma

Carcinoma Of Scrotum	Malignant Neoplasm Of Scrotum
Neoplasm Of Scrotum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112825	TSI-01		98.31%	Unkown
HY-RS07765	LPCAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LPCAT2	RGD	RGD:2325051
Bos taurus	LPCAT2	VGNC	VGNC:30962
Macaca mulatta	LPCAT2	VGNC	VGNC:74365
Felis catus	LPCAT2	VGNC	VGNC:63265
Canis familiaris	LPCAT2	VGNC	VGNC:42749
Mus musculus	LPCAT2	MGD	MGI:3606214

Name
Email *

	Sorry, but the email address you supplied was invalid.