2. Gene
  3. ACP3 - acid phosphatase 3 Gene

ACP3 - acid phosphatase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACPP; 5'-NT; ACP-3; TM-PAP

Gene ID: 55 | Gene type: protein coding

About ACP3

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:132,317,407-132,368,302 (from NCBI)

This gene has 9 transcripts (splice variants), 165 orthologues and 5 paralogues. Restricted expression toward prostate (RPKM 1149.8).

Summary

This gene encodes an Enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

ACP3 Products(3)

mRNA Protein Name
NM_001099.5 NP_001090.2 prostatic acid phosphatase isoform PAP precursor
NM_001134194.2 NP_001127666.1 prostatic acid phosphatase isoform TM-PAP precursor
NM_001292037.2 NP_001278966.1 prostatic acid phosphatase isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
18940592 GOA
enables acid phosphatase activity IDA
IDA: Inferred from direct assay
10506173 GOA
enables acid phosphatase activity IMP
IMP: Inferred from mutant phenotype
8132635 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18083097 GOA
enables lysophosphatidic acid phosphatase activity IDA
IDA: Inferred from direct assay
15280042 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
19995078 GOA
enables phosphatase activity IMP
IMP: Inferred from mutant phenotype
18940592 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9705354 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10639192 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenosine metabolic process IDA
IDA: Inferred from direct assay
18940592 GOA
involved in dephosphorylation IMP
IMP: Inferred from mutant phenotype
8132635 GOA
involved in positive regulation of adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18940592 GOA
involved in regulation of sensory perception of pain IMP
IMP: Inferred from mutant phenotype
18940592 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
10639192 GOA
located in extracellular space IMP
IMP: Inferred from mutant phenotype
22389722 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17658863 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACP3 Protein Structure

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (34 - 331)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

prostatic acid phosphatase

TMPase

ACP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ACP3 P15309 ERBB2 Homo sapiens P04626
Genetic Interference
9705354
Intra
ACP3 P15309 ERBB2 Homo sapiens P04626
Phosphatase Assay
9705354
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
Fluorescence
24657436
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
Cosedimentation
18083097
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
TEM
24657436
Intra
ACP3 P15309 ACP3 Homo sapiens P15309
CD
18083097
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACP3 Proteins

Cat. No. Product Name Accession Purity
HY-P7817 Prostatic acid phosphatase/ACPP Protein, Human (354a.a, HEK293, His, solution) AAH16344.1 (K33-D386) ≥95%
HY-P7817A Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His) NP_001127666.1 (K33-K382) ≥95%
HY-P700619 Prostatic acid Phosphatase/ACPP Protein, Human (HEK293, GFP-His) P15309 (K33-K382) ≥95%
HY-P700620 Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His) P15309 (K33-I418) ≥95%

Related Diseases

Diseases Alias
Prostatitis
Clear Cell Adenocarcinoma

Mesonephroma

Water-Clear Cell Adenocarcinoma

Adenocarcinoma, Clear Cell

Malignant Mesonephroma

Mesonephroid Clear Cell Carcinoma

Mesonephroma, Malignant

Water-Clear Cell Carcinoma

Wolffian Duct Neoplasm

Adenocarcinoma Clear Cell

Mesonephric Tumor
Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp
Cerebrovascular Benign Neoplasm
Phosphatase, Acid, Of Tissues

Lysosomal Acid Phosphatase

Acp3--Alpha Polypeptide
Choroid Plexus Cancer

Choroid Plexus Carcinoma

Choroid Plexus Neoplasms

Choroid Plexus Neoplasm

Tumor Of Choroid Plexus

Tumor Of The Choroid Plexus

Choroid Plexus Tumor

Choroid Plexus Tumors

Anaplastic Choroid Plexus Papilloma

Choroid Plexus Papilloma Nos

Papilloma Of Choroid Plexus

Plexus Choroideus Papilloma

Choroid Plexus Papilloma In Fourth Ventricle

Plexus Choroideus Papilloma In Fourth Ventricle
Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia

BPH

Prostatic Hyperplasia
Prostatic Adenoma

Prostatic Hyperplasia

Adenoma - Prostate

Adenoma Of Prostate

Benign Adenoma Of Prostate

Prostate Adenoma

Benign Prostatic Hyperplasia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Combined Oxidative Phosphorylation Deficiency 17

COXPD17

Combined Oxidative Phosphorylation Defect Type 17

Combined Oxidative Phosphorylation Deficiency, Type 17
Prostate Disease

Prostatic Diseases

Prostate Diseases
Papilloma Of Choroid Plexus

Choroid Plexus Papilloma

CPP

Childhood Choroid Plexus Papilloma

Papilloma Choroid Plexus

Papilloma, Choroid Plexus

Choroid Plexus Carcinoma
Endodermal Sinus Tumor

Yolk Sac Tumor

Endodermal Sinus Tumour

Hepatoid Yolk Sac Tumour

Infantile Embryonal Carcinoma

Yolk Sac Neoplasm

Yolk Sac Tumour
Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms

Cerebral Ventricle Neoplasm

Intraventricular Tumor Of Brain
Cerebrum Cancer

Cerebral Cancer

Neoplasm Of Cerebrum

Tumor Of Cerebrum

Malignant Neoplasm Of Cerebrum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00188 ACP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACP3 RGD RGD:2023
Bos taurus ACP3 VGNC VGNC:52603
Canis familiaris ACP3 VGNC VGNC:54915
Mus musculus ACP3 MGD MGI:1928480
Macaca mulatta ACP3 VGNC VGNC:69385
Felis catus ACP3 VGNC VGNC:59528
Others ACP3 NCBI