PAK1IP1 - PAK1 interacting protein 1 Gene

Homo sapiens

Also known as PIP1; MAK11; WDR84; hPIP1; bA421M1.5

Gene ID: 55003 | Gene type: protein coding

About PAK1IP1

Cytogenetic location: 6p24.2 Genomic coordinates (GRCh38): 6:10,690,865-10,709,782 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 198 orthologues and 26 paralogues. Ubiquitous expression in prostate (RPKM 23.6), appendix (RPKM 6.7) and 24 other tissues.

Summary

Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

PAK1IP1 Products(1)

mRNA	Protein	Name
NM_017906.3	NP_060376.2	p21-activated protein kinase-interacting protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25074804	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	24120868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK1IP1 Protein Structure

WD40

0
100
200
300
392 a.a.

Protein Preferred Names

Protein Names

p21-activated protein kinase-interacting protein 1

PAK/PLC-interacting protein 1

PAK1IP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637
Intra	PAK1IP1	Q9NWT1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PAK1IP1	Q9NWT1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	PAK1IP1	Q9NWT1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Kidney Rhabdoid Cancer

Rhabdoid Tumor Of The Kidney	Kidney Rhabdoid Tumor
Renal Rhabdoid Tumor

Non-Syndromic X-Linked Intellectual Disability 30

Mrx30	Mrx47
X-Linked Mental Retardation 30/47	X-Linked Mental Retardation 47
Mental Retardation, X-Linked, Type 30/47

Orofacial Cleft 1

OFC1	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1
Orofacial Cleft, Nonsyndromic	Ofc
Cleft Lip/Palate, Nonsyndromic	Orofacial Cleft-1
Nonsyndromic Cleft Lip With Or Without Cleft Palate 1	Nonsyndromic Cleft Lip Palate
Otofaciocervical Syndrome 1

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09986	PAK1IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PAK1IP1	VGNC	VGNC:75661
Felis catus	PAK1IP1	VGNC	VGNC:64026
Rattus norvegicus	PAK1IP1	RGD	RGD:1565353
Mus musculus	PAK1IP1	MGD	MGI:1915333
Canis familiaris	PAK1IP1	VGNC	VGNC:44244
Bos taurus	PAK1IP1	VGNC	VGNC:32555

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