PPP1R1A - protein phosphatase 1 regulatory inhibitor subunit 1A Gene

Homo sapiens

Also known as I1; IPP1

Gene ID: 5502 | Gene type: protein coding

About PPP1R1A

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,579,246-54,588,659 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Biased expression in fat (RPKM 174.0), kidney (RPKM 33.7) and 3 other tissues.

Summary

Predicted to enable protein serine/threonine Phosphatase Inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PPP1R1A Products(1)

mRNA	Protein	Name
NM_006741.4	NP_006732.3	protein phosphatase 1 regulatory subunit 1A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11564868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R1A Protein Structure

DARPP-32

0
100
171 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 1A

I-1

PPP1R1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R1A	Q13522	PPP1R15A	Homo sapiens	O75807	Y2H	11564868

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP1R1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70987	PPP1R1A Protein, Human (His)	AAH22470.1 (M1-V171)	≥95%

Related Diseases

Diseases

Alias

Simple Partial Epilepsy

Epilepsy, Simple Partial

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10992	PPP1R1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PPP1R1A	VGNC	VGNC:58287
Mus musculus	PPP1R1A	MGD	MGI:1889595
Macaca mulatta	PPP1R1A	VGNC	VGNC:76368
Felis catus	PPP1R1A	VGNC	VGNC:69000
Bos taurus	PPP1R1A	VGNC	VGNC:54472
Rattus norvegicus	PPP1R1A	RGD	RGD:62018
Others	PPP1R1A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.