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  2. PPP1R15A - protein phosphatase 1 regulatory subunit 15A Gene

PPP1R15A - protein phosphatase 1 regulatory subunit 15A Gene

Homo sapiens

Also known as GADD34

Gene ID: 23645 | Gene type: protein coding

About PPP1R15A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,872,421-48,876,058 (from NCBI)

This gene has 5 transcripts (splice variants), 112 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 214.4), gall bladder (RPKM 51.1) and 23 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with Apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

PPP1R15A Products(1)

mRNA Protein Name
NM_014330.5 NP_055145.3 protein phosphatase 1 regulatory subunit 15A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11564868 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11517336 GOA
enables protein phosphatase 1 binding IDA
IDA: Inferred from direct assay
11564868 GOA
enables protein phosphatase 1 binding IPI
IPI: Inferred from physical interaction
12556489 GOA
enables protein phosphatase regulator activity IDA
IDA: Inferred from direct assay
12556489 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein localization to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
12556489 GOA
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
11564868 GOA
involved in regulation of translational initiation in response to stress IDA
IDA: Inferred from direct assay
11564868 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
12556489 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
21518769 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21518769 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12556489 GOA
located in membrane IDA
IDA: Inferred from direct assay
21518769 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
21518769 GOA
part of protein phosphatase type 1 complex IDA
IDA: Inferred from direct assay
11564868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R15A Protein Structure

PP1c_bdg

PP1c_bdg: Phosphatase-1 catalytic subunit binding region (544 - 619)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 15A

growth arrest and DNA damage-inducible protein GADD34

PPP1R15A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1R15A O75807 PPP1R1A Homo sapiens Q13522
Pull Down
11564868
Intra
PPP1R15A O75807 PPP1R1A Homo sapiens Q13522
Y2H
11564868
Intra
PPP1R15A O75807 PPP1CA Homo sapiens P62136
Y2H
15231748
Intra
PPP1R15A O75807 PPP1CA Homo sapiens P62136
FPS
26095357
Intra
PPP1R15A O75807 PPP1CA Homo sapiens P62136
Pull Down
29109149
Intra
PPP1R15A O75807 PPP1CA Homo sapiens P62136
Anti Tag CoIP
29109149
Intra
PPP1R15A O75807 PPP1CA Homo sapiens P62136
Anti Tag CoIP
26095357
Intra
PPP1R15A O75807 TARDBP Homo sapiens Q13148
Pull Down
29109149
Intra
PPP1R15A O75807 TARDBP Homo sapiens Q13148
Anti Tag CoIP
29109149
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome

Med-Iddm Syndrome

Iddm-Med Syndrome

Wolcott Rallison Syndrome

WRS

Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus

Charcot-Marie-Tooth Disease, Demyelinating, Type 1b

Charcot-Marie-Tooth Disease Type 1b

CMT1B

Hereditary Motor And Sensory Neuropathy Ib

Hmsn Ib

Hmsn1b

Peroneal Muscular Atrophy

Charcot-Marie-Tooth Disease, Type 1b

Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Linked To Duffy

Charcot-Marie-Tooth Neuropathy Type 1b

Charcot-Marie-Tooth Disease, Type Ib

Hereditary Motor And Sensory Neuropathy I

Hmsn I

Hmsn1

Charcot-Marie-Tooth Neuropathy, Type 1b

Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy

Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1b

Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1b

Charcot-Marie-Tooth Disease 1b

Charcot-Marie-Tooth Disease Demyelinating Type 1b

Hmsn Type I

Hereditary Motor And Sensory Neuropathy Type I

Charcot-Marie-Tooth Disease

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PPP1R15A VGNC VGNC:53754
Mus musculus PPP1R15A MGD MGI:1927072
Bos taurus PPP1R15A VGNC VGNC:33228
Rattus norvegicus PPP1R15A RGD RGD:621526
Macaca mulatta PPP1R15A VGNC VGNC:76254