PID1 - phosphotyrosine interaction domain containing 1 Gene

Homo sapiens

Also known as PCLI1; NYGGF4; P-CLI1; HMFN2073

Gene ID: 55022 | Gene type: protein coding

About PID1

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,023,973-229,271,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in brain (RPKM 7.9), liver (RPKM 5.4) and 24 other tissues.

Summary

Involved in several processes, including mitochondrion morphogenesis; negative regulation of phosphate metabolic process; and positive regulation of macromolecule metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PID1 Products(5)

mRNA	Protein	Name
NM_001100818.2	NP_001094288.1	PTB-containing, cubilin and LRP1-interacting protein isoform 2
NM_001330156.1	NP_001317085.1	PTB-containing, cubilin and LRP1-interacting protein isoform 3
NM_001330157.2	NP_001317086.1	PTB-containing, cubilin and LRP1-interacting protein isoform 4
NM_001330158.2	NP_001317087.1	PTB-containing, cubilin and LRP1-interacting protein isoform 5
NM_017933.5	NP_060403.3	PTB-containing, cubilin and LRP1-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in fat cell differentiation	IDA IDA: Inferred from direct assay	16815647	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in negative regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19079291	GOA
involved in positive regulation of fat cell proliferation	IDA IDA: Inferred from direct assay	16815647	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20165904	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16815647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PID1 Protein Structure

PID_2

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

PTB-containing, cubilin and LRP1-interacting protein

phosphotyrosine interaction domain-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10480	PID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PID1	VGNC	VGNC:32862
Canis familiaris	PID1	VGNC	VGNC:44526
Rattus norvegicus	PID1	RGD	RGD:1560766
Felis catus	PID1	VGNC	VGNC:80302
Macaca mulatta	PID1	VGNC	VGNC:75869
Mus musculus	PID1	MGD	MGI:2138391

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