PID1 - phosphotyrosine interaction domain containing 1 Gene

Homo sapiens

Also known as PCLI1; NYGGF4; P-CLI1; HMFN2073

Gene ID: 55022 | Gene type: protein coding

About PID1

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,023,973-229,271,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in brain (RPKM 7.9), liver (RPKM 5.4) and 24 other tissues.

Summary

Involved in several processes, including mitochondrion morphogenesis; negative regulation of phosphate metabolic process; and positive regulation of macromolecule metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PID1 Products(5)

mRNA	Protein	Name
NM_001100818.2	NP_001094288.1	PTB-containing, cubilin and LRP1-interacting protein isoform 2
NM_001330156.1	NP_001317085.1	PTB-containing, cubilin and LRP1-interacting protein isoform 3
NM_001330157.2	NP_001317086.1	PTB-containing, cubilin and LRP1-interacting protein isoform 4
NM_001330158.2	NP_001317087.1	PTB-containing, cubilin and LRP1-interacting protein isoform 5
NM_017933.5	NP_060403.3	PTB-containing, cubilin and LRP1-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in fat cell differentiation	IDA IDA: Inferred from direct assay	16815647	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in negative regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19079291	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19079291	GOA
involved in positive regulation of fat cell proliferation	IDA IDA: Inferred from direct assay	16815647	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20165904	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20165904	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16815647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PID1 Protein Structure

PID_2

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

PTB-containing, cubilin and LRP1-interacting protein

phosphotyrosine interaction domain-containing protein 1

PID1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PID1	Q7Z2X4	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	PID1	Q7Z2X4	GOPC	Homo sapiens	Q9HD26	Validated Y2H	25416956
Intra	PID1	Q7Z2X4	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	PID1	Q7Z2X4	q96t11_human	Homo sapiens	Q96T11	Anti Tag CoIP	33961781
Intra	PID1	Q7Z2X4	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	NME1	Homo sapiens	P15531	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	NME1	Homo sapiens	P15531	Y2H Array	25416956
Intra	PID1	Q7Z2X4	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	PID1	Q7Z2X4	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	PID1	Q7Z2X4	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	PID1	Q7Z2X4	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	PID1	Q7Z2X4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	PID1	Q7Z2X4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10480	PID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PID1	VGNC	VGNC:32862
Canis familiaris	PID1	VGNC	VGNC:44526
Rattus norvegicus	PID1	RGD	RGD:1560766
Felis catus	PID1	VGNC	VGNC:80302
Macaca mulatta	PID1	VGNC	VGNC:75869
Mus musculus	PID1	MGD	MGI:2138391

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