DYNC2I1 - dynein 2 intermediate chain 1 Gene

Homo sapiens (human)

Also known as DIC6; SRPS6; SRTD8; WDR60; FAP163; CFAP163

Gene ID: 55112 | Gene type: protein coding

About DYNC2I1

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, Apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]

DYNC2I1 Products(1)

mRNA	Protein	Name
XM_054358568.1	XP_054214543.1	cytoplasmic dynein 2 intermediate chain 1 isoform X10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein light chain binding	IPI IPI: Inferred from physical interaction	25830415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IGI IGI: Inferred from genetic interaction	25205765	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	23910462	GOA
involved in embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	23910462	GOA
involved in intraciliary retrograde transport	IDA IDA: Inferred from direct assay	29742051	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	25830415	GOA
located in centrosome	IDA IDA: Inferred from direct assay	31451806	GOA
colocalizes with ciliary base	IDA IDA: Inferred from direct assay	25830415	GOA
located in ciliary base	IDA IDA: Inferred from direct assay	23910462	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA
colocalizes with interphase microtubule organizing center	IDA IDA: Inferred from direct assay	25830415	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	25205765	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	25830415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic dynein 2 intermediate chain 1

WD repeat domain 60	WD repeat-containing protein 60
testicular secretory protein Li 66

DYNC2I1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNC2I1	Q8WVS4	DYNC2I2	Homo sapiens	Q96EX3	GMS	31451806
Intra	DYNC2I1	Q8WVS4	DYNC2I2	Homo sapiens	Q96EX3	Anti Tag CoIP	33961781
Intra	DYNC2I1	Q8WVS4	DYNC2I2	Homo sapiens	Q96EX3	3D-EM-Single	31451806
Intra	DYNC2I1	Q8WVS4	DYNC2I2	Homo sapiens	Q96EX3	TAP	27173435
Intra	DYNC2I1	Q8WVS4	NUDC	Homo sapiens	Q9Y266	TAP	27173435
Intra	DYNC2I1	Q8WVS4	NUDC	Homo sapiens	Q9Y266	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04083	DYNC1I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04086	DYNC2H1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04087	DYNC2LI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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