DYNC2I2 - dynein 2 intermediate chain 2 Gene

Homo sapiens (human)

Also known as DIC5; WDR34; FAP133; SRTD11; CFAP133; bA216B9.3

Gene ID: 89891 | Gene type: protein coding

About DYNC2I2

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]

DYNC2I2 Products(1)

mRNA	Protein	Name
XM_011519179.3	XP_011517481.1	cytoplasmic dynein 2 intermediate chain 2 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein light chain binding	IPI IPI: Inferred from physical interaction	25830415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IGI IGI: Inferred from genetic interaction	25205765	GOA
involved in intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	29742051	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	25205765	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	25205765	GOA
located in cilium	IDA IDA: Inferred from direct assay	25205765	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25205765	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic dynein 2 intermediate chain 2

WD repeat domain 34

WD repeat-containing protein 34

DYNC2I2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNC2I2	Q96EX3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	DYNC2I2	Q96EX3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	DYNC2I2	Q96EX3	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	DYNC2I2	Q96EX3	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	DYNC2I2	Q96EX3	DYNC2I1	Homo sapiens	Q8WVS4	TAP	27173435
Intra	DYNC2I2	Q96EX3	COIL	Homo sapiens	P38432	Y2H Array	25416956
Intra	DYNC2I2	Q96EX3	COIL	Homo sapiens	P38432	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04084	DYNC1I2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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