AKIRIN2 - akirin 2 Gene

Homo sapiens

Also known as FBI1; C6orf166; dJ486L4.2

Gene ID: 55122 | Gene type: protein coding

About AKIRIN2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,674,860-87,702,233 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 25.3), spleen (RPKM 21.1) and 24 other tissues.

Summary

Enables Enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of interleukin-6 production and response to lipopolysaccharide. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AKIRIN2 Products(1)

mRNA	Protein	Name
NM_018064.4	NP_060534.1	akirin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	34711951	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive effect nuclear protein quality control by the ubiquitin-proteasome system	IDA IDA: Inferred from direct assay	34711951	GOA
involved in proteasome localization	IDA IDA: Inferred from direct assay	34711951	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	34711951	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18066067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

akirin-2

fourteen-three-three beta interactant 1

AKIRIN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKIRIN2	Q53H80	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	AKIRIN2	Q53H80	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	AKIRIN2	Q53H80	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	AKIRIN2	Q53H80	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	AKIRIN2	Q53H80	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	AKIRIN2	Q53H80	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	AKIRIN2	Q53H80	HSD17B14	Homo sapiens	Q9BPX1	Y2H Prey Pooling	32296183
Intra	AKIRIN2	Q53H80	HSD17B14	Homo sapiens	Q9BPX1	Validated Y2H	32296183
Intra	AKIRIN2	Q53H80	HSD17B14	Homo sapiens	Q9BPX1	Y2H Array	32296183
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Anti Tag CoIP	33961781
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Anti Tag CoIP	28514442
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	AKIRIN2	Q53H80	SPG21	Homo sapiens	Q9NZD8	Y2H Array	31515488
Intra	AKIRIN2	Q53H80	AKIRIN2	Homo sapiens	Q53H80	Validated Y2H	32296183
Intra	AKIRIN2	Q53H80	AKIRIN2	Homo sapiens	Q53H80	Y2H Array	32296183
Intra	AKIRIN2	Q53H80	AKIRIN2	Homo sapiens	Q53H80	Y2H Prey Pooling	32296183
Intra	AKIRIN2	Q53H80	RAN	Homo sapiens	P62826	Anti Tag CoIP	28514442
Intra	AKIRIN2	Q53H80	RAN	Homo sapiens	P62826	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Zebrafish Allergy

Danio Rerio Allergy

Tick Infestation

Tick Infestations

Metacarpal 4-5 Fusion

Syndactyly Type 8	MF4
Fusion Of Metacarpals 4 And 5	Metacarpals 4 And 5 Fusion
Metacarpal 4 5 Fusion

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Tick Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00528	AKIRIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKIRIN2	VGNC	VGNC:25794
Mus musculus	AKIRIN2	MGD	MGI:1889364
Canis familiaris	AKIRIN2	VGNC	VGNC:37766
Felis catus	AKIRIN2	VGNC	VGNC:59721
Rattus norvegicus	AKIRIN2	RGD	RGD:1307791
Macaca mulatta	AKIRIN2	VGNC	VGNC:69665

Name
Email *

	Sorry, but the email address you supplied was invalid.