1. Gene
  2. SORBS3 - sorbin and SH3 domain containing 3 Gene

SORBS3 - sorbin and SH3 domain containing 3 Gene

Homo sapiens

Also known as SCAM1; SH3D4; SCAM-1

Gene ID: 10174 | Gene type: protein coding

About SORBS3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,544,973-22,575,788 (from NCBI)

This gene has 22 transcripts (splice variants), 206 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 30.7), testis (RPKM 27.8) and 24 other tissues.

Summary

This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind Other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SORBS3 Products(2)

mRNA Protein Name
NM_001018003.3 NP_001018003.1 vinexin isoform 2
NM_005775.5 NP_005766.3 vinexin isoform 1

SORBS3 Protein Structure

Sorb

Sorb: Sorbin homologous domain (120 - 156)

SH3_9

SH3_9: Variant SH3 domain (388 - 435)

SH3_1

SH3_1: SH3 domain (460 - 507)

SH3_9

SH3_9: Variant SH3 domain (619 - 669)

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  • 600
  • 671 a.a.
Protein Preferred Names Protein Names

vinexin

sorbin and SH3 domain-containing protein 3

SORBS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SORBS3 O60504 CCDC102B Homo sapiens Q68D86 32296183
Intra
SORBS3 O60504 PNMA5 Homo sapiens Q96PV4 32296183
Intra
SORBS3 O60504 CCHCR1 Homo sapiens Q8TD31-3 32296183
Intra
SORBS3 O60504 HNRNPUL1 Homo sapiens Q9BUJ2 25416956
Intra
SORBS3 O60504 HNRNPUL1 Homo sapiens Q9BUJ2 25416956
Intra
SORBS3 O60504 EIF3S3 Homo sapiens Q6IB98 25416956
Intra
SORBS3 O60504 IQUB Homo sapiens Q8NA54 32296183
Intra
SORBS3 O60504 DIP2A Homo sapiens Q14689-6 25416956
Intra
SORBS3 O60504 TSGA10IP Homo sapiens Q3SY00 32296183
Intra
SORBS3 O60504 VARS2 Homo sapiens Q5ST30-4 25416956
Intra
SORBS3 O60504 NFKBID Homo sapiens Q8NI38 32296183
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2 25416956
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2 25416956
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788-2 25416956
Intra
SORBS3 O60504 CCDC6 Homo sapiens Q16204 32296183
Intra
SORBS3 O60504 PAK2 Homo sapiens Q13177
Y2H
21516116
Intra
SORBS3 O60504 PAK2 Homo sapiens Q13177 16374509
Intra
SORBS3 O60504 GAS8 Homo sapiens O95995 32296183
Intra
SORBS3 O60504 RAD51D Homo sapiens O75771 32296183
Intra
SORBS3 O60504 CCDC57 Homo sapiens Q2TAC2-2 32296183
Intra
SORBS3 O60504 VCL Homo sapiens P18206-2 32296183
Intra
SORBS3 O60504 ABI2 Homo sapiens Q9NYB9-2 32296183
Intra
SORBS3 O60504 TEPSIN Homo sapiens Q96N21 32296183
Intra
SORBS3 O60504 NEK6 Homo sapiens Q9HC98-4 32296183
Intra
SORBS3 O60504 ANKS1A Homo sapiens Q49AR9 32296183
Intra
SORBS3 O60504 TCEANC Homo sapiens Q8N8B7-2 32296183
Intra
SORBS3 O60504 FBXL19 Homo sapiens Q6PCT2-2 32296183
Intra
SORBS3 O60504 RUNX1T1 Homo sapiens Q06455-2 32296183
Intra
SORBS3 O60504 PLEKHN1 Homo sapiens Q494U1-3 32296183
Intra
SORBS3 O60504 GLRA1 Homo sapiens P23415 32296183
Intra
SORBS3 O60504 INSC Homo sapiens Q1MX18 32296183
Intra
SORBS3 O60504 SYNPO2L Homo sapiens Q9H987-2 32296183
Intra
SORBS3 O60504 PPIL6 Homo sapiens Q8IXY8 32296183
Intra
SORBS3 O60504 SETD5 Homo sapiens Q9C0A6-3 32296183
Intra
SORBS3 O60504 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
SORBS3 O60504 PIBF1 Homo sapiens Q4G0R1 32296183
Intra
SORBS3 O60504 KIFC3 Homo sapiens Q9BVG8-5 32296183
Intra
SORBS3 O60504 MGC50722 Homo sapiens Q8IVT4 32296183
Intra
SORBS3 O60504 ZC2HC1C Homo sapiens Q53FD0-2 32296183
Intra
SORBS3 O60504 PHETA1 Homo sapiens Q8N4B1-4 32296183
Intra
SORBS3 O60504 SOCS7 Homo sapiens O14512
IF
15242778
Intra
SORBS3 O60504 SOCS7 Homo sapiens O14512 15242778
Intra
SORBS3 O60504 CPNE8 Homo sapiens Q86YQ8 32296183
Intra
SORBS3 O60504 CPNE1 Homo sapiens Q99829 32296183
Intra
SORBS3 O60504 FAM53C Homo sapiens Q9NYF3 32296183
Intra
SORBS3 O60504 PPFIA3 Homo sapiens O75145 32296183
Intra
SORBS3 O60504 VARS2 Homo sapiens Q5ST30 32296183
Intra
SORBS3 O60504 MKRN3 Homo sapiens Q13064 32296183
Intra
SORBS3 O60504 NAF1 Homo sapiens Q96HR8 32296183
Intra
SORBS3 O60504 CHERP Homo sapiens Q8IWX8 32296183
Intra
SORBS3 O60504 KANK2 Homo sapiens Q63ZY3 32296183
Intra
SORBS3 O60504 PPP1R18 Homo sapiens Q6NYC8 32296183
Intra
SORBS3 O60504 CCNL1 Homo sapiens Q9UK58 32296183
Intra
SORBS3 O60504 WIPF2 Homo sapiens Q8TF74 32296183
Intra
SORBS3 O60504 NHSL2 Homo sapiens Q5HYW2 32296183
Intra
SORBS3 O60504 AKT2 Homo sapiens P31751 32296183
Intra
SORBS3 O60504 HNRNPK Homo sapiens P61978 25416956
Intra
SORBS3 O60504 HNRNPK Homo sapiens P61978 25416956
Intra
SORBS3 O60504 QARS1 Homo sapiens P47897 32296183
Intra
SORBS3 O60504 DDX6 Homo sapiens P26196 32296183
Intra
SORBS3 O60504 HNRNPF Homo sapiens P52597 32296183
Intra
SORBS3 O60504 TXLNA Homo sapiens P40222 32296183
Intra
SORBS3 O60504 RIN1 Homo sapiens Q13671 32296183
Intra
SORBS3 O60504 COG4 Homo sapiens Q9H9E3 32296183
Intra
SORBS3 O60504 ADAT3 Homo sapiens Q96EY9 32296183
Intra
SORBS3 O60504 SAXO1 Homo sapiens Q8IYX7 25416956
Intra
SORBS3 O60504 CDC23 Homo sapiens Q9UJX2 32296183
Intra
SORBS3 O60504 VPS37B Homo sapiens Q9H9H4 25416956
Intra
SORBS3 O60504 VPS37B Homo sapiens Q9H9H4 25416956
Intra
SORBS3 O60504 RTKN Homo sapiens Q9BST9
Y2H
19294487
Intra
SORBS3 O60504 HNRNPK Homo sapiens P61978-2 32296183
Intra
SORBS3 O60504 CPNE2 Homo sapiens Q96FN4 25416956
Intra
SORBS3 O60504 CPNE2 Homo sapiens Q96FN4 32296183
Intra
SORBS3 O60504 CPNE2 Homo sapiens Q96FN4 25416956
Intra
SORBS3 O60504 CDKN2C Homo sapiens P42773 32296183
Intra
SORBS3 O60504 POLE2 Homo sapiens P56282 32296183
Intra
SORBS3 O60504 POLE2 Homo sapiens P56282 32296183
Intra
SORBS3 O60504 TRIM27 Homo sapiens P14373 25416956
Intra
SORBS3 O60504 TRIM27 Homo sapiens P14373 25416956
Intra
SORBS3 O60504 TRIM41 Homo sapiens Q8WV44 25416956
Intra
SORBS3 O60504 KIAA0408 Homo sapiens Q6ZU52 25416956
Intra
SORBS3 O60504 KIAA0408 Homo sapiens Q6ZU52 25416956
Intra
SORBS3 O60504 CRACR2A Homo sapiens Q9BSW2 32296183
Intra
SORBS3 O60504 DVL3 Homo sapiens Q92997 32296183
Intra
SORBS3 O60504 TRIM23 Homo sapiens P36406 25416956
Intra
SORBS3 O60504 TRIM23 Homo sapiens P36406 32296183
Intra
SORBS3 O60504 TRIM23 Homo sapiens P36406 25416956
Intra
SORBS3 O60504 GYS1 Homo sapiens P13807 32296183
Intra
SORBS3 O60504 CCNH Homo sapiens P51946 32296183
Intra
SORBS3 O60504 PLOD3 Homo sapiens O60568 32296183
Intra
SORBS3 O60504 PAK5 Homo sapiens Q9P286 25416956
Intra
SORBS3 O60504 SPG21 Homo sapiens Q9NZD8 32296183
Intra
SORBS3 O60504 AKIRIN2 Homo sapiens Q53H80 32296183
Intra
SORBS3 O60504 EFHC1 Homo sapiens Q5JVL4 32296183
Intra
SORBS3 O60504 USP2 Homo sapiens O75604 32296183
Intra
SORBS3 O60504 ENKD1 Homo sapiens Q9H0I2 32296183
Intra
SORBS3 O60504 GEM Homo sapiens P55040 32296183
Intra
SORBS3 O60504 ZNF414 Homo sapiens Q96IQ9 32296183
Intra
SORBS3 O60504 CATSPER1 Homo sapiens Q8NEC5 32296183
Intra
SORBS3 O60504 CCDC120 Homo sapiens Q96HB5 32296183
Intra
SORBS3 O60504 TSGA10 Homo sapiens Q9BZW7 32296183
Intra
SORBS3 O60504 FNDC11 Homo sapiens Q9BVV2 32296183
Intra
SORBS3 O60504 ATOSB Homo sapiens Q7L5A3 32296183
Intra
SORBS3 O60504 GPKOW Homo sapiens Q92917 32296183
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788 25416956
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788 25416956
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788 32296183
Intra
SORBS3 O60504 SH2D4A Homo sapiens Q9H788 25416956
Intra
SORBS3 O60504 IMP3 Homo sapiens Q9NV31 32296183
Intra
SORBS3 O60504 TEAD4 Homo sapiens Q15561 32296183
Intra
SORBS3 O60504 SCNM1 Homo sapiens Q9BWG6 32296183
Intra
SORBS3 O60504 CFAP206 Homo sapiens Q8IYR0 32296183
Intra
SORBS3 O60504 NRBP1 Homo sapiens Q9UHY1 32296183
Intra
SORBS3 O60504 GPANK1 Homo sapiens O95872 32296183
Intra
SORBS3 O60504 NAB2 Homo sapiens Q15742 32296183
Intra
SORBS3 O60504 AIRIM Homo sapiens Q9NX04 32296183
Intra
SORBS3 O60504 TBC1D22B Homo sapiens Q9NU19 25416956
Intra
SORBS3 O60504 TBC1D22B Homo sapiens Q9NU19 29892012
Intra
SORBS3 O60504 OSGIN1 Homo sapiens Q9UJX0 32296183
Intra
SORBS3 O60504 TNS2 Homo sapiens Q63HR2 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, X-Linked 2

Scax2

X-Linked Spinocerebellar Ataxia 2

Cerebellar Ataxia With Extrapyramidal Involvement Early-Onset

Cerebellar Ataxia With Extrapyramidal Involvement, Early-Onset

Spinocerebellar Ataxia X-Linked Type 2

Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p

CMD1P

Cardiomyopathy, Dilated 1p

Cardiomyopathy, Dilated, Type 1p

Spinocerebellar Ataxia, Autosomal Recessive 3

SCAR3

Scabd

Autosomal Recessive Spinocerebellar Ataxia Type 3

Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome

Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome

Spinocerebellar Ataxia With Blindness And Deafness

Autosomal Recessive Spinocerebellar Ataxia 3

Spinocerebellar Ataxia Autosomal Recessive 3

Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness

Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome

Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv

Schizophrenia 18

SCZD18

Schizophrenia 18 With Or Without An Affective Disorder

Schizophrenia Susceptibility 18

Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Schizophrenia, Type 18

X-Linked Cerebellar Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SORBS3 VGNC VGNC:65570
Canis familiaris SORBS3 VGNC VGNC:46658
Mus musculus SORBS3 MGD MGI:700013
Macaca mulatta SORBS3 VGNC VGNC:77803
Bos taurus SORBS3 VGNC VGNC:35129
Rattus norvegicus SORBS3 RGD RGD:628900