HEATR1 - HEAT repeat containing 1 Gene

Homo sapiens

Also known as BAP28; UTP10

Gene ID: 55127 | Gene type: protein coding

About HEATR1

This gene has 5 transcripts (splice variants) and 239 orthologues. Ubiquitous expression in testis (RPKM 12.5), appendix (RPKM 11.0) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in fibrillar center and mitochondrion. Implicated in pancreatic ductal carcinoma. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]

HEATR1 Products(1)

mRNA	Protein	Name
NM_018072.6	NP_060542.4	HEAT repeat-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22190034	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	38225354	GOA
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	17699751	GOA
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	17699751	GOA
involved in protein localization to nucleolus	IDA IDA: Inferred from direct assay	38225354	GOA
acts upstream of rRNA metabolic process	IMP IMP: Inferred from mutant phenotype	38225354	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	17699751	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HEATR1 Protein Structure

U3snoRNP10

BP28CT

0
400
800
1200
1600
2000
2144 a.a.

Protein Preferred Names

Protein Names

HEAT repeat-containing protein 1

U3 small nucleolar RNA-associated protein 10 homolog

HEATR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	HEATR1	Q9H583	q76353_9hiv1	Human immunodeficiency virus	Q76353	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatic Ductal Carcinoma

Carcinoma, Pancreatic Ductal	Malignant Neoplasm Of Duct Of Wirsung
Pancreatic Duct Cancer	Carcinoma Pancreatic Ductal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06101	HEATR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HEATR1	VGNC	VGNC:73230
Canis familiaris	HEATR1	VGNC	VGNC:41633
Rattus norvegicus	HEATR1	RGD	RGD:1564769
Bos taurus	HEATR1	VGNC	VGNC:29791
Mus musculus	HEATR1	MGD	MGI:2442524

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