TMEM33 - transmembrane protein 33 Gene

Homo sapiens

Also known as Pom33; SHINC3; SHINC-3; 1600019D15Rik

Gene ID: 55161 | Gene type: protein coding

About TMEM33

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,935,137-41,960,803 (from NCBI)

This gene has 8 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues.

Summary

Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM33 Products(1)

mRNA	Protein	Name
NM_018126.3	NP_060596.2	transmembrane protein 33

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17215244	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of IRE1-mediated unfolded protein response	IDA IDA: Inferred from direct assay	26268696	GOA
involved in positive regulation of PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	26268696	GOA
involved in regulation of endoplasmic reticulum tubular network organization	IDA IDA: Inferred from direct assay	25612671	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	26268696	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25612671	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25612671	GOA
located in melanosome	IDA IDA: Inferred from direct assay	17081065	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	25612671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM33 Protein Structure

UPF0121

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 33

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14717	TMEM33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM33	RGD	RGD:708371
Macaca mulatta	TMEM33	VGNC	VGNC:79511
Felis catus	TMEM33	VGNC	VGNC:107476
Canis familiaris	TMEM33	VGNC	VGNC:47571
Bos taurus	TMEM33	VGNC	VGNC:36076
Mus musculus	TMEM33	MGD	MGI:1915128

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