MSL2 - MSL complex subunit 2 Gene

Homo sapiens

Also known as MSL-2; MSL2L1; RNF184

Gene ID: 55167 | Gene type: protein coding

About MSL2

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:136,148,917-136,196,335 (from NCBI)

This gene has 8 transcripts (splice variants), 263 orthologues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 16.6), lymph node (RPKM 11.8) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Involved in histone H4-K16 acetylation. Part of MSL complex. [provided by Alliance of Genome Resources, Apr 2022]

MSL2 Products(2)

mRNA	Protein	Name
NM_001145417.2	NP_001138889.1	E3 ubiquitin-protein ligase MSL2 isoform 2
NM_018133.4	NP_060603.2	E3 ubiquitin-protein ligase MSL2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H2B ubiquitin ligase activity	IDA IDA: Inferred from direct assay	21726816	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16227571	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19033443	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19033443	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	21726816	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
is active in chromatin	IDA IDA: Inferred from direct assay	21726816	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16227571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MSL2

E3 ubiquitin-protein transferase MSL2

MSL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSL2	Q9HCI7	MSL1	Homo sapiens	Q68DK7	Anti Tag CoIP	28514442
Intra	MSL2	Q9HCI7	MSL1	Homo sapiens	Q68DK7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Basilicata-Akhtar Syndrome

Mrxs36	MRXSBA
Mental Retardation, X-Linked, Syndromic, Basilicata-Akhtar Type	Mental Retardation, X-Linked, Syndromic 36
X-Linked Syndromic Mental Retardation 36	X-Linked Syndromic Mental Retardation Basilicata-Akhtar Type

Atrial Septal Defect 3

ASD3	Atrial Heart Septal Defect 3
Septal Defect, Atrial, Type 3

Koolen-De Vries Syndrome

KDVS	17q21.31 Microdeletion Syndrome
Microdeletion 17q21.31 Syndrome	Chromosome 17q21.31 Deletion Syndrome
Koolen De Vries Syndrome	Kansl1-Related Intellectual Disability Syndrome
Chromosome 17q21.31 Microdeletion Syndrome	Monosomy 17q21.31
17q21.31 Deletion Syndrome	Koolen Syndrome
Del(17)(Q21.31)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08717	MSL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MSL2	VGNC	VGNC:63636
Rattus norvegicus	MSL2	RGD	RGD:1310355
Bos taurus	MSL2	VGNC	VGNC:31699
Mus musculus	MSL2	MGD	MGI:1925103
Macaca mulatta	MSL2	VGNC	VGNC:74827
Canis familiaris	MSL2	VGNC	VGNC:43444

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