FAIM - Fas apoptotic inhibitory molecule Gene

Homo sapiens

Also known as FAIM1

Gene ID: 55179 | Gene type: protein coding

About FAIM

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,608,771-138,633,376 (from NCBI)

This gene has 9 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in fat (RPKM 4.9), thyroid (RPKM 4.0) and 25 other tissues.

Summary

The protein encoded by this gene protects against death receptor-triggered Apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FAIM Products(4)

mRNA	Protein	Name
NM_001033030.2	NP_001028202.1	fas apoptotic inhibitory molecule 1 isoform a
NM_001033031.2	NP_001028203.1	fas apoptotic inhibitory molecule 1 isoform b
NM_001033032.2	NP_001028204.1	fas apoptotic inhibitory molecule 1 isoform c
NM_018147.4	NP_060617.1	fas apoptotic inhibitory molecule 1 isoform c

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAIM Protein Structure

FAIM1

0
100
179 a.a.

Protein Preferred Names

Protein Names

fas apoptotic inhibitory molecule 1

FAIM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAIM	Q9NVQ4	WDR47	Homo sapiens	O94967	Anti Tag CoIP	33961781
Intra	FAIM	Q9NVQ4	SPRY2	Homo sapiens	O43597	Validated Y2H	25416956
Intra	FAIM	Q9NVQ4	SPRY2	Homo sapiens	O43597	Y2H Array	25416956
Intra	FAIM	Q9NVQ4	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10	OI10
Osteogenesis Imperfecta Type X	Oi, Type X
Osteogenesis Imperfecta 10	Oi Type X
Oi-X

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Kwashiorkor

Kwashiokor	Nutritional Edema With Dyspigmentation Of Skin And Hair
Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04674	FAIM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04675	FAIM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FAIM	VGNC	VGNC:72297
Mus musculus	FAIM	MGD	MGI:1344387
Rattus norvegicus	FAIM	RGD	RGD:620572
Felis catus	FAIM	VGNC	VGNC:102694
Bos taurus	FAIM	VGNC	VGNC:28709
Canis familiaris	FAIM	VGNC	VGNC:40570

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