2. Gene
  3. SPRY2 - sprouty RTK signaling antagonist 2 Gene

SPRY2 - sprouty RTK signaling antagonist 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IGAN3; hSPRY2

Gene ID: 10253 | Gene type: protein coding

About SPRY2

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:80,335,976-80,341,126 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to Fibroblast Growth Factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on Fibroblast Growth Factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

SPRY2 Products(4)

mRNA Protein Name
NM_001318536.1 NP_001305465.1 protein sprouty homolog 2
NM_001318537.1 NP_001305466.1 protein sprouty homolog 2
NM_001318538.1 NP_001305467.1 protein sprouty homolog 2
NM_005842.4 NP_005833.1 protein sprouty homolog 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12815057 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20736167 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
18070883 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to vascular endothelial growth factor stimulus IDA
IDA: Inferred from direct assay
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21536891 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
20489163 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24177325 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
20736167 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
17974561 GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway IDA
IDA: Inferred from direct assay
21536891 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20489163 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
18070883 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18070883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRY2 Protein Structure

Sprouty

Sprouty: Sprouty protein (Spry) (183 - 294)

  • 0
  • 100
  • 200
  • 315 a.a.
Protein Preferred Names Protein Names

protein sprouty homolog 2

SPRY2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra
SPRY2 O43597 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP10-11 Homo sapiens P60412
Y2H Array
25416956
Intra
SPRY2 O43597 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
Intra
SPRY2 O43597 PTGER3 Homo sapiens P43115-12
Y2H Array
25416956
Intra
SPRY2 O43597 PTGER3 Homo sapiens P43115-12
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 q5jpt6_human Homo sapiens Q5JPT6
Y2H Array
25416956
Intra
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8
Validated Y2H
25416956
Intra
SPRY2 O43597 LCE3C Homo sapiens Q5T5A8
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0
Validated Y2H
25416956
Intra
SPRY2 O43597 LCE3E Homo sapiens Q5T5B0
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Array
29892012
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Y2H Array
31515488
Intra
SPRY2 O43597 LCE1B Homo sapiens Q5T7P3
Validated Y2H
25416956
Intra
SPRY2 O43597 LCE4A Homo sapiens Q5TA78
Y2H Array
25416956
Intra
SPRY2 O43597 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Validated Y2H
25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Y2H Array
25416956
Intra
SPRY2 O43597 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Array
25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
Intra
SPRY2 O43597 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Validated Y2H
25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Y2H Array
25416956
Intra
SPRY2 O43597 SHFL Homo sapiens Q9NUL5
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra
SPRY2 O43597 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
Intra
SPRY2 O43597 UBASH3B Homo sapiens Q8TF42
Validated Y2H
25416956
Intra
SPRY2 O43597 GP9 Homo sapiens P14770
Y2H Array
25416956
Intra
SPRY2 O43597 GP9 Homo sapiens P14770
Validated Y2H
25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H Array
25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 UBASH3A Homo sapiens P57075
Y2H
21516116
Intra
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8
Validated Y2H
25416956
Intra
SPRY2 O43597 LONRF1 Homo sapiens Q17RB8
Y2H Array
25416956
Intra
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6
Validated Y2H
25416956
Intra
SPRY2 O43597 USP20 Homo sapiens Q9Y2K6
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0
Validated Y2H
25416956
Intra
SPRY2 O43597 TXNDC5 Homo sapiens Q86UY0
Y2H Array
25416956
Intra
SPRY2 O43597 SH3KBP1 Homo sapiens Q96B97
Anti Tag CoIP
15962011
Intra
SPRY2 O43597 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
SPRY2 O43597 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Y2H Array
25416956
Intra
SPRY2 O43597 EIF4E2 Homo sapiens O60573
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 GRB2 Homo sapiens P62993
Filter Binding
16893902
Intra
SPRY2 O43597 GRB2 Homo sapiens P62993
Anti Bait CoIP
16893902
Intra
SPRY2 O43597 GNE Homo sapiens Q9Y223
Validated Y2H
25416956
Intra
SPRY2 O43597 GNE Homo sapiens Q9Y223
Y2H Array
25416956
Intra
SPRY2 O43597 CBL Homo sapiens P22681
Anti Tag CoIP
18273061
Intra
SPRY2 O43597 CBL Homo sapiens P22681
Anti Bait CoIP
16893902
Intra
SPRY2 O43597 CBL Homo sapiens P22681
ITC
18273061
Intra
SPRY2 O43597 CBL Homo sapiens P22681
Anti Tag CoIP
15962011
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Validated Y2H
25416956
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
25416956
Intra
SPRY2 O43597 ZDHHC17 Homo sapiens Q8IUH5
Anti Tag CoIP
33961781
Intra
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
25416956
Intra
SPRY2 O43597 HEXIM2 Homo sapiens Q96MH2
Y2H Array
25416956
Intra
SPRY2 O43597 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
SPRY2 O43597 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra
SPRY2 O43597 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Pooling
16189514
Intra
SPRY2 O43597 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
Intra
SPRY2 O43597 GRAP2 Homo sapiens O75791
Y2H Array
25416956
Intra
SPRY2 O43597 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242
Y2H
21516116
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 OTX1 Homo sapiens P32242
Validated Y2H
25416956
Intra
SPRY2 O43597 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 AQP1 Homo sapiens P29972
Y2H Array
25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra
SPRY2 O43597 ATRIP Homo sapiens Q8WXE1
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
SPRY2 O43597 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra
SPRY2 O43597 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
SPRY2 O43597 TCAF1 Homo sapiens Q9Y4C2
Y2H Array
25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Y2H Array
25416956
Intra
SPRY2 O43597 PACSIN3 Homo sapiens Q9UKS6
Validated Y2H
25416956
Intra
SPRY2 O43597 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
Intra
SPRY2 O43597 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
Intra
SPRY2 O43597 CHRD Homo sapiens Q9H2X0
Y2H Array
25416956
Intra
SPRY2 O43597 CHRD Homo sapiens Q9H2X0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Iga Nephropathy 3

Iga Nephropathy, Susceptibility To, 3

IGAN3

{Iga Nephropathy, Susceptibility To, 3}
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma
Focal Segmental Glomerulosclerosis 3

FSGS3

Focal Segmental Glomerulosclerosis 3, Susceptibility To

Glomerulosclerosis, Focal Segmental, 3

Glomerulosclerosis, Focal Segmental, 3, Susceptibility To

Glomerulosclerosis, Segmental, Focal, Type 3, Susceptibility To
Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome
Achondroplasia

Achondroplastic Dwarfism

ACH

Osteosclerosis Congenita

Achondroplastic Physique

Chondrodystrophia

Dwarf, Achondroplastic

Achondroplastic Short Stature

Congenital Osteosclerosis
Lacrimoauriculodentodigital Syndrome

Ladd Syndrome

Levy-Hollister Syndrome

Lacrimo-Auriculo-Dento-Digital Syndrome

LADD

Lacrimoauriculodento-Digital Syndrome

Levy Hollister Syndrome

Lard Syndrome

Lacrimoauriculoradiodental Syndrome

LADDS

Congenital Duodenal Obstruction Due To Malrotation Of Intestine
Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Van Der Woude Syndrome

Lip-Pit Syndrome

Vws

Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip

Vdws

Lps

Lip Pit Syndrome

Cleft Lip/Palate With Mucous Cysts Of Lower Lip

Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Orofacial Cleft

Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13722 SPRY2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPRY2 VGNC VGNC:35242
Mus musculus SPRY2 MGD MGI:1345138
Felis catus SPRY2 VGNC VGNC:65650
Rattus norvegicus SPRY2 RGD RGD:1311472
Macaca mulatta SPRY2 VGNC VGNC:106300
Canis familiaris SPRY2 VGNC VGNC:46766