SPRY2 - sprouty RTK signaling antagonist 2 Gene

Homo sapiens

Also known as IGAN3; hSPRY2

Gene ID: 10253 | Gene type: protein coding

About SPRY2

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:80,335,976-80,341,126 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 17.3), gall bladder (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to Fibroblast Growth Factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on Fibroblast Growth Factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

SPRY2 Products(4)

mRNA	Protein	Name
NM_001318536.1	NP_001305465.1	protein sprouty homolog 2
NM_001318537.1	NP_001305466.1	protein sprouty homolog 2
NM_001318538.1	NP_001305467.1	protein sprouty homolog 2
NM_005842.4	NP_005833.1	protein sprouty homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12815057	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20736167	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	18070883	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	21536891	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21536891	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20489163	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24177325	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18070883	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	20736167	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	17974561	GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	21536891	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18070883	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20489163	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18070883	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18070883	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18070883	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRY2 Protein Structure

Sprouty

0
100
200
315 a.a.

Protein Preferred Names

Protein Names

protein sprouty homolog 2

Related Diseases

Diseases

Alias

Iga Nephropathy 3

Iga Nephropathy, Susceptibility To, 3	IGAN3
{Iga Nephropathy, Susceptibility To, 3}

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Focal Segmental Glomerulosclerosis 3

FSGS3	Focal Segmental Glomerulosclerosis 3, Susceptibility To
Glomerulosclerosis, Focal Segmental, 3	Glomerulosclerosis, Focal Segmental, 3, Susceptibility To
Glomerulosclerosis, Segmental, Focal, Type 3, Susceptibility To

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome	Nfls
LGSS	Neurofibromatosis 1-Like Syndrome
Neurofibromatosis Type 1 Like Syndrome	Nf1-Like Syndrome
Neurofibromatosis, Type 1-Like Syndrome

Achondroplasia

Achondroplastic Dwarfism	ACH
Osteosclerosis Congenita	Achondroplastic Physique
Chondrodystrophia	Dwarf, Achondroplastic
Achondroplastic Short Stature	Congenital Osteosclerosis

Lacrimoauriculodentodigital Syndrome

Ladd Syndrome	Levy-Hollister Syndrome
Lacrimo-Auriculo-Dento-Digital Syndrome	LADD
Lacrimoauriculodento-Digital Syndrome	Levy Hollister Syndrome
Lard Syndrome	Lacrimoauriculoradiodental Syndrome
LADDS	Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Van Der Woude Syndrome

Lip-Pit Syndrome	Vws
Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip	Vdws
Lps	Lip Pit Syndrome
Cleft Lip/Palate With Mucous Cysts Of Lower Lip	Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments

Orofacial Cleft

Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13722	SPRY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPRY2	VGNC	VGNC:35242
Mus musculus	SPRY2	MGD	MGI:1345138
Felis catus	SPRY2	VGNC	VGNC:65650
Rattus norvegicus	SPRY2	RGD	RGD:1311472
Macaca mulatta	SPRY2	VGNC	VGNC:106300
Canis familiaris	SPRY2	VGNC	VGNC:46766

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