GOLPH3L - golgi phosphoprotein 3 like Gene

Homo sapiens

Also known as GPP34R

Gene ID: 55204 | Gene type: protein coding

About GOLPH3L

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,646,230-150,697,154 (from NCBI)

This gene has 3 transcripts (splice variants), 273 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 16.0), thyroid (RPKM 15.0) and 25 other tissues.

Summary

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

GOLPH3L Products(1)

mRNA	Protein	Name
NM_018178.6	NP_060648.2	Golgi phosphoprotein 3-like

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cargo adaptor activity	IDA IDA: Inferred from direct assay	34473204	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	23345592	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	23345592	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	23345592	GOA
involved in protein targeting to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	34473204	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11042173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOLPH3L Protein Structure

GPP34

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

Golgi phosphoprotein 3-like

GPP34-related protein

GOLPH3L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GOLPH3L	Q9H4A5	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	GOLPH3L	Q9H4A5	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	GOLPH3L	Q9H4A5	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	GOLPH3L	Q9H4A5	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	GOLPH3L	Q9H4A5	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	GOLPH3L	Q9H4A5	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	GOLPH3L	Q9H4A5	HTT	Homo sapiens	P42858	Lumier	23275563
Intra	GOLPH3L	Q9H4A5	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	GOLPH3L	Q9H4A5	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	GOLPH3L	Q9H4A5	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05595	GOLPH3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GOLPH3L	MGD	MGI:1917129
Bos taurus	GOLPH3L	VGNC	VGNC:29493
Macaca mulatta	GOLPH3L	VGNC	VGNC:73003
Canis familiaris	GOLPH3L	VGNC	VGNC:41346
Rattus norvegicus	GOLPH3L	RGD	RGD:1359281
Felis catus	GOLPH3L	VGNC	VGNC:80223

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