EXD2 - exonuclease 3'-5' domain containing 2 Gene

Homo sapiens

Also known as EXDL2; C14orf114

Gene ID: 55218 | Gene type: protein coding

About EXD2

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,191,498-69,244,018 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.7), brain (RPKM 8.0) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in nucleic acid metabolic process. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

EXD2 Products(5)

mRNA	Protein	Name
NM_001193360.2	NP_001180289.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193361.2	NP_001180290.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193362.2	NP_001180291.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193363.2	NP_001180292.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_018199.4	NP_060669.1	exonuclease 3'-5' domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	26807646	GOA
enables 3'-5' exonuclease activity	IMP IMP: Inferred from mutant phenotype	31255466	GOA
enables 3'-5'-DNA exonuclease activity	IDA IDA: Inferred from direct assay	31127291	GOA
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	31127291	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	31127291	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	31127291	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26807646	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	31127291	GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA IDA: Inferred from direct assay	26807646	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA double-strand break processing	IDA IDA: Inferred from direct assay	26807646	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	26807646	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	26807646	GOA
involved in nucleic acid metabolic process	IDA IDA: Inferred from direct assay	26807646	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	31255466	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29599527	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	31255466	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXD2 Protein Structure

DNA_pol_A_exo1

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

exonuclease 3'-5' domain-containing protein 2

3'-5' exoribonuclease EXD2

EXD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EXD2	Q9NVH0	RBBP8	Homo sapiens	Q99708	Anti Tag CoIP	26807646

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04583	EXD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EXD2	RGD	RGD:1311087
Macaca mulatta	EXD2	VGNC	VGNC:81401
Canis familiaris	EXD2	VGNC	VGNC:40509
Felis catus	EXD2	VGNC	VGNC:80976
Bos taurus	EXD2	VGNC	VGNC:28640
Mus musculus	EXD2	MGD	MGI:1922485

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