1. Gene
  2. TRIM62 - tripartite motif containing 62 Gene

TRIM62 - tripartite motif containing 62 Gene

Homo sapiens

Also known as DEAR1

Gene ID: 55223 | Gene type: protein coding

About TRIM62

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,145,399-33,182,043 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 2.0), brain (RPKM 1.3) and 25 other tissues.

Summary

Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of Antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM62 Products(2)

mRNA Protein Name
NM_001330483.2 NP_001317412.1 E3 ubiquitin-protein ligase TRIM62 isoform 2
NM_018207.3 NP_060677.2 E3 ubiquitin-protein ligase TRIM62 isoform 1

TRIM62 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (11 - 53)

zf-B_box

zf-B_box: B-box zinc finger (90 - 126)

PRY

PRY: SPRY-associated domain (297 - 346)

SPRY

SPRY: SPRY domain (348 - 457)

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  • 475 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM62

RING-type E3 ubiquitin transferase TRIM62

Related Diseases

Diseases Alias
Ring Chromosome 1

Chromosome 1 Ring

R1

Ring 1

Ring Chromosome 1 Syndrome

R(1) Syndrome

Ring Chromosome
Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

IMD27B

Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant

Ifngr1 Deficiency, Autosomal Dominant

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27b, Mycobacteriosis, Ad

Autosomal Dominant Ifngr1 Deficiency

Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis

Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Immunodeficiency 27a

IMD27A

Autosomal Recessive Ifngr1 Deficiency

Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency

Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency

Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency

Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive

Ifngr1 Deficiency, Autosomal Recessive

Immunodeficiency 27a, Mycobacteriosis, Ar

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Ifngammar1 Deficiency

Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency

Familial Disseminated Atypical Mycobacterial Infection

Interferon Gamma, Receptor 1, Deficiency

Immunodeficiency, Type 27a, Mycobacteriosis, Ar

Mycobacterial Disease, Mendelian Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus TRIM62 VGNC VGNC:66547
Mus musculus TRIM62 MGD MGI:1914775
Macaca mulatta TRIM62 VGNC VGNC:79513
Bos taurus TRIM62 VGNC VGNC:36345
Rattus norvegicus TRIM62 RGD RGD:1586169
Canis familiaris TRIM62 VGNC VGNC:47830