TRIM62 - tripartite motif containing 62 Gene

Homo sapiens

Also known as DEAR1

Gene ID: 55223 | Gene type: protein coding

About TRIM62

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,145,399-33,182,043 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 2.0), brain (RPKM 1.3) and 25 other tissues.

Summary

Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of Antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM62 Products(2)

mRNA	Protein	Name
NM_001330483.2	NP_001317412.1	E3 ubiquitin-protein ligase TRIM62 isoform 2
NM_018207.3	NP_060677.2	E3 ubiquitin-protein ligase TRIM62 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	26488816	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23402750	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	18248090	GOA
involved in negative regulation of viral transcription	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of antifungal innate immune response	IDA IDA: Inferred from direct assay	26488816	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	26488816	GOA
involved in regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	18248090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	26488816	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23402750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM62 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM62

RING-type E3 ubiquitin transferase TRIM62

TRIM62 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM62	Q9BVG3	SP7	Homo sapiens	Q8TDD2	Y2H Array	32296183
Intra	TRIM62	Q9BVG3	SP7	Homo sapiens	Q8TDD2	Y2H Prey Pooling	32296183
Intra	TRIM62	Q9BVG3	FAIM	Homo sapiens	Q9NVQ4-2	Validated Y2H	32296183
Intra	TRIM62	Q9BVG3	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	TRIM62	Q9BVG3	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	TRIM62	Q9BVG3	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	TRIM62	Q9BVG3	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	TRIM62	Q9BVG3	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	TRIM62	Q9BVG3	TRIM62	Homo sapiens	Q9BVG3	Complementation	32296183
Intra	TRIM62	Q9BVG3	TRIM62	Homo sapiens	Q9BVG3	MAPPIT	32296183
Intra	TRIM62	Q9BVG3	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	TRIM62	Q9BVG3	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	TRIM62	Q9BVG3	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ring Chromosome 1

Chromosome 1 Ring	R1
Ring 1	Ring Chromosome 1 Syndrome
R(1) Syndrome

Ring Chromosome

Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency	IMD27B
Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant	Ifngr1 Deficiency, Autosomal Dominant
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27b, Mycobacteriosis, Ad
Autosomal Dominant Ifngr1 Deficiency	Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis
Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Immunodeficiency 27a

IMD27A	Autosomal Recessive Ifngr1 Deficiency
Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive
Ifngr1 Deficiency, Autosomal Recessive	Immunodeficiency 27a, Mycobacteriosis, Ar
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency	Msmd Due To Complete Ifngammar1 Deficiency
Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency
Familial Disseminated Atypical Mycobacterial Infection	Interferon Gamma, Receptor 1, Deficiency
Immunodeficiency, Type 27a, Mycobacteriosis, Ar	Mycobacterial Disease, Mendelian Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115497	BRD5529	Inhibitor	98.94%	Unkown
HY-RS15062	TRIM62 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRIM62	VGNC	VGNC:66547
Mus musculus	TRIM62	MGD	MGI:1914775
Macaca mulatta	TRIM62	VGNC	VGNC:79513
Bos taurus	TRIM62	VGNC	VGNC:36345
Rattus norvegicus	TRIM62	RGD	RGD:1586169
Canis familiaris	TRIM62	VGNC	VGNC:47830

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