2. Gene
  3. NAT10 - N-acetyltransferase 10 Gene

NAT10 - N-acetyltransferase 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALP; Kre33; NET43

Gene ID: 55226 | Gene type: protein coding

About NAT10

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,105,629-34,146,908 (from NCBI)

This gene has 9 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

NAT10 Products(2)

mRNA Protein Name
NM_001144030.2 NP_001137502.2 RNA cytidine acetyltransferase isoform b
NM_024662.3 NP_078938.3 RNA cytidine acetyltransferase isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA polymerase binding IPI
IPI: Inferred from physical interaction
18082603 GOA
enables N-acetyltransferase activity EXP
EXP: Inferred from Experiment
25411247 GOA
enables mRNA N-acetyltransferase activity IDA
IDA: Inferred from direct assay
30449621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25653167 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
18082603 GOA
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
30449621 GOA
involved in protein acetylation IDA
IDA: Inferred from direct assay
31722219 GOA
involved in regulation of centrosome duplication IDA
IDA: Inferred from direct assay
31722219 GOA
involved in regulation of translation IDA
IDA: Inferred from direct assay
35679869 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
18082603 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
part of telomerase holoenzyme complex IDA
IDA: Inferred from direct assay
18082603 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAT10 Protein Structure

DUF1726

DUF1726: Domain of unknown function (DUF1726) (107 - 201)

Helicase_RecD

Helicase_RecD: Helicase (282 - 488)

GNAT_acetyltr_2

GNAT_acetyltr_2: GNAT acetyltransferase 2 (529 - 752)

tRNA_bind_2

tRNA_bind_2: Possible tRNA binding domain (771 - 890)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1025 a.a.
Protein Preferred Names Protein Names

RNA cytidine acetyltransferase

18S rRNA cytosine acetyltransferase

NAT10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NAT10 Q9H0A0 RPS2 Homo sapiens P15880
Crosslink
30021884
Intra
NAT10 Q9H0A0 RPS2 Homo sapiens P15880
Anti Tag CoIP
33961781
Intra
NAT10 Q9H0A0 THUMPD1 Homo sapiens Q9NXG2
Anti Bait CoIP
25653167
Intra
NAT10 Q9H0A0 THUMPD1 Homo sapiens Q9NXG2
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach
Microphthalmia, Syndromic 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome

MCOPS13

Maine Microphthalmos

Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation

Syndromic Microphthalmia 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome

Microphthalmia, Syndromic, 13

Microphthalmia, Syndromic, Type 13
Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy

Congenital Muscular Dystrophy Due To Lmna Mutation

MDCL

L-Cmd

Lmna-Related Congenital Muscular Dystrophy

Muscular Dystrophy, Congenital

Congenital Muscular Dystrophy Lmna-Related

Lmna-Related Cmd

Cmd

Mdc

Muscular Dystrophy Congenital Lmna-Related

Dystrophy, Muscular, Congenital, Lmna-Related

Dystrophy, Muscular, Congenital

Hereditary Muscular Dystrophy

Congenital Hereditary Muscular Dystrophy

Congenital Progressive Muscular Dystrophy

Hereditary Progressive Muscular Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16706A Remodelin hydrobromide Inhibitor 99.52% Unkown
HY-16706 Remodelin Inhibitor 99.79% Unkown
HY-120317 CPTH2-Alkyne Inhibitor / Unkown
HY-RS09040 NAT10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NAT10 VGNC VGNC:43627
Macaca mulatta NAT10 VGNC VGNC:75046
Bos taurus NAT10 VGNC VGNC:31888
Rattus norvegicus NAT10 RGD RGD:1306717
Felis catus NAT10 VGNC VGNC:63726
Mus musculus NAT10 MGD MGI:2138939