FEM1A - fem-1 homolog A Gene

Homo sapiens

Also known as EPRAP

Gene ID: 55527 | Gene type: protein coding

About FEM1A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,791,734-4,801,273 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 4 paralogues.

Summary

Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin Ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FEM1A Products(1)

mRNA	Protein	Name
NM_018708.3	NP_061178.1	protein fem-1 homolog A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables EP4 subtype prostaglandin E2 receptor binding	IPI IPI: Inferred from physical interaction	16424369	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	16424369	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29779948	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	16424369	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29779948	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	16424369	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	19406122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEM1A Protein Structure

Ank

Ank_2

Ank_4

Ank_2

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

protein fem-1 homolog A

FEM1-alpha

FEM1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FEM1A	Q9BSK4	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	FEM1A	Q9BSK4	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	FEM1A	Q9BSK4	MALT1	Homo sapiens	Q9UDY8-2	Y2H Prey Pooling	32296183
Intra	FEM1A	Q9BSK4	MALT1	Homo sapiens	Q9UDY8-2	Validated Y2H	32296183
Intra	FEM1A	Q9BSK4	MALT1	Homo sapiens	Q9UDY8-2	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	FEM1A	Q9BSK4	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	FEM1A	Q9BSK4	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	FEM1A	Q9BSK4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	FEM1A	Q9BSK4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	FEM1A	Q9BSK4	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rhabdomyosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04858	FEM1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FEM1A	VGNC	VGNC:108244
Mus musculus	FEM1A	MGD	MGI:1335089
Felis catus	FEM1A	VGNC	VGNC:62224
Rattus norvegicus	FEM1A	RGD	RGD:1561112
Bos taurus	FEM1A	VGNC	VGNC:28944

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