PSPC1 - paraspeckle component 1 Gene

Homo sapiens

Also known as PSP1

Gene ID: 55269 | Gene type: protein coding

About PSPC1

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,671,205-19,782,945 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 5.7), bone marrow (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

PSPC1 Products(4)

mRNA	Protein	Name
NM_001042414.4	NP_001035879.1	paraspeckle component 1 isoform 1
NM_001354908.2	NP_001341837.1	paraspeckle component 1 isoform 2
NM_001354909.2	NP_001341838.1	paraspeckle component 1 isoform 1
NM_001363660.2	NP_001350589.1	paraspeckle component 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	22416126	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16148043	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	22416126	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in paraspeckles	IDA IDA: Inferred from direct assay	11790299	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSPC1 Protein Structure

RRM_1

NOPS

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

paraspeckle component 1

paraspeckle protein 1

PSPC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Anti Tag CoIP	16148043
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Y2H Prey Pooling	25416956
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Anti Bait CoIP	16148043
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Anti Tag CoIP	35271311
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Y2H Array	25416956
Intra	PSPC1	Q8WXF1	NONO	Homo sapiens	Q15233	Validated Y2H	25416956
Intra	PSPC1	Q8WXF1	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	35271311
Intra	PSPC1	Q8WXF1	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	PSPC1	Q8WXF1	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11340	PSPC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSPC1	RGD	RGD:1310122
Mus musculus	PSPC1	MGD	MGI:1913895
Felis catus	PSPC1	VGNC	VGNC:64417
Bos taurus	PSPC1	VGNC	VGNC:33482
Macaca mulatta	PSPC1	VGNC	VGNC:76293

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