NONO - non-POU domain containing octamer binding Gene

Homo sapiens

Also known as P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114

Gene ID: 4841 | Gene type: protein coding

About NONO

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,283,635-71,301,168 (from NCBI)

This gene has 40 transcripts (splice variants), 217 orthologues, 7 paralogues and is associated with 62 phenotypes. Ubiquitous expression in ovary (RPKM 81.7), lymph node (RPKM 64.3) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

NONO Products(4)

mRNA	Protein	Name
NM_001145408.2	NP_001138880.1	non-POU domain-containing octamer-binding protein isoform 1
NM_001145409.2	NP_001138881.1	non-POU domain-containing octamer-binding protein isoform 1
NM_001145410.2	NP_001138882.1	non-POU domain-containing octamer-binding protein isoform 2
NM_007363.5	NP_031389.3	non-POU domain-containing octamer-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16148043	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15790595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15790595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear matrix	IDA IDA: Inferred from direct assay	19874820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15790595	GOA
is active in paraspeckles	IDA IDA: Inferred from direct assay	19716791	GOA
located in paraspeckles	IDA IDA: Inferred from direct assay	19217333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NONO Protein Structure

RRM_1

NOPS

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

non-POU domain-containing octamer-binding protein

54 kDa nuclear RNA- and DNA-binding protein

NONO Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3-3	Validated Y2H	32296183
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1-2	Anti Tag CoIP	28514442
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1-2	Validated Y2H	32296183
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Pull Down	16148043
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Anti Tag CoIP	33961781
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Y2H Array	25416956
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Anti Tag CoIP	16148043
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Y2H Pooling	16169070
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Y2H	21988832
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	35271311
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Crosslink	30021884
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	28514442
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	33961781
Intra	NONO	Q15233	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	NONO	Q15233	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	NONO	Q15233	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	NONO	Q15233	PIN1	Homo sapiens	Q13526	Y2H Pooling	16189514
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3	Validated Y2H	25416956
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NONO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81661	NONO Antibody (YA1406)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic 34

MRXS34	Mental Retardation, X-Linked, Syndromic, Mircsof-Langouet Type
Mrxsml	Mental Retardation, X-Linked, Syndromic 34
Intellectual Developmental Disorder, X-Linked Syndromic 34	Mental Retardation, X-Linked, Syndromic, Type 34

Syndromic X-Linked Intellectual Disability 34

Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome	Mental Retardation, X-Linked, Syndromic 34
Mrxs34	Mrxsml
Syndromic X-Linked Mental Retardation Mircsof-Langouet Type

Renal Cell Carcinoma, Xp11-Associated

RCCX1	Mit Family Translocation Renal Cell Carcinoma
Renal Cell Carcinoma, Papillary, 1	Carcinoma Associated With Mitf/Tfe Translocation
Translocation Renal Cell Carcinoma	Renal Cell Carcinoma Xp11-Associated
Renal Cell Carcinoma Papillary 1	Carcinoma, Renal Cell, Xp11-Associated

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor	Neuroendocrine Tumor Of The Small Intestine
Net Of The Small Intestine	Neuroendocrine Neoplasm Of The Small Intestine
Neuroendocrine Tumor Of Small Bowel	Small Intestinal Neuroendocrine Neoplasm

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Perivascular Epithelioid Cell Tumor

Pecoma	Perivascular Epithelioid Cell Neoplasms
Neoplasm With Perivascular Epithelioid Cell Differentiation

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153918	(R)-SKBG-1	Inhibitor	99.50%	Unkown
HY-153918A	(S)-SKBG-1		99.01%	Unkown
HY-108960	PPADS	Antagonist	/	Unkown
HY-RS09425	NONO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NONO	VGNC	VGNC:75367
Rattus norvegicus	NONO	RGD	RGD:1549738
Mus musculus	NONO	MGD	MGI:1855692
Bos taurus	NONO	VGNC	VGNC:32163
Canis familiaris	NONO	VGNC	VGNC:54178
Others	NONO	NCBI

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