BRF2 - BRF2 RNA polymerase III transcription initiation factor subunit Gene

Homo sapiens

Also known as BRFU; TFIIIB50

Gene ID: 55290 | Gene type: protein coding

About BRF2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,843,268-37,849,861 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues.

Summary

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

BRF2 Products(1)

mRNA	Protein	Name
NM_018310.4	NP_060780.2	transcription factor IIIB 50 kDa subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26638071	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	26638071	GOA
involved in regulation of transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	26638071	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription factor TFIIIB complex	IMP IMP: Inferred from mutant phenotype	26638071	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRF2 Protein Structure

TF_Zn_Ribbon

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

transcription factor IIIB 50 kDa subunit

B-related factor 2

BRF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BRF2	Q9HAW0	JUP	Homo sapiens	P14923	Anti Tag CoIP	33961781
Intra	BRF2	Q9HAW0	JUP	Homo sapiens	P14923	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cone-Rod Dystrophy 9

CORD9	Dystrophy, Cone-Rod, Type 9
Retinitis Pigmentosa 9

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01617	BRF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRF2	RGD	RGD:1308817
Felis catus	BRF2	VGNC	VGNC:60173
Macaca mulatta	BRF2	VGNC	VGNC:70335
Mus musculus	BRF2	MGD	MGI:1913903
Bos taurus	BRF2	VGNC	VGNC:26563
Canis familiaris	BRF2	VGNC	VGNC:38524

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