PPP3CA - protein phosphatase 3 catalytic subunit alpha Gene

Homo sapiens

Also known as CALN; CCN1; CNA1; CALNA; DEE91; IECEE; PPP2B; ACCIID; CALNA1; IECEE1

Gene ID: 5530 | Gene type: protein coding

About PPP3CA

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:101,023,418-101,347,526 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues, 12 paralogues and is associated with 6 phenotypes. Broad expression in brain (RPKM 54.0), prostate (RPKM 42.7) and 24 other tissues.

Summary

Enables several functions, including ATPase binding activity; Calmodulin binding activity; and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Located in several cellular components, including cytosol; dendritic spine; and nucleoplasm. Part of Calcineurin complex. Colocalizes with cytoplasmic side of plasma membrane. Implicated in developmental and epileptic encephalopathy 91. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PPP3CA Products(3)

mRNA	Protein	Name
NM_000944.5	NP_000935.1	protein phosphatase 3 catalytic subunit alpha isoform 1
NM_001130691.2	NP_001124163.1	protein phosphatase 3 catalytic subunit alpha isoform 2
NM_001130692.2	NP_001124164.1	protein phosphatase 3 catalytic subunit alpha isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	15955804	GOA
enables calmodulin binding	EXP EXP: Inferred from Experiment	18384083	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	11005320	GOA
enables calmodulin binding	IPI IPI: Inferred from physical interaction	18384083	GOA
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	18815128	GOA
enables calmodulin-dependent protein phosphatase activity	IMP IMP: Inferred from mutant phenotype	30254215	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	11005320	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8524402	GOA
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11005320	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	30718414	GOA
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	30611118	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	19154138	GOA
involved in calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	15955804	GOA
involved in calcineurin-mediated signaling	IMP IMP: Inferred from mutant phenotype	11005320	GOA
involved in negative regulation of angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	30718414	GOA
involved in peptidyl-serine dephosphorylation	IMP IMP: Inferred from mutant phenotype	30611118	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	21785830	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20422345	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22688515	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	18815128	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	18815128	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcineurin complex	IDA IDA: Inferred from direct assay	12218175	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15955804	GOA
colocalizes with cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	22343722	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	22343722	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15955804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3CA Protein Structure

Metallophos

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 3 catalytic subunit alpha

CAM-PRP catalytic subunit

PPP3CA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP3CA	Q08209	USP14	Homo sapiens	P54578	Anti Tag CoIP	19896943
Intra	PPP3CA	Q08209	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	PPP3CA	Q08209	GRB2	Homo sapiens	P62993	Y2H	21900206
Intra	PPP3CA	Q08209	C16orf74	Homo sapiens	Q96GX8	Y2H Pooling	16189514
Intra	PPP3CA	Q08209	C16orf74	Homo sapiens	Q96GX8	Y2H Prey Pooling	25416956
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Validated Y2H	25416956
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	X-Ray Diffraction	8524402
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Lumier	32814053
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Anti Tag CoIP	33961781
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Lumier	37398436
Cross	PPP3CA	Q08209	Cacng8	Rattus norvegicus	Q8VHW5	Anti Bait CoIP	24418105

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP3CA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76759	Calcineurin A/PPP3CA Protein, Human (sf9, His)	Q08209-1 (S2-Q521)	≥95%

Related Diseases

Diseases

Alias

Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development

ACCIID

Craniosynostosis-Microretrognathia-Severe Intellectual Disability Syndrome

Developmental And Epileptic Encephalopathy 91

Epileptic Encephalopathy, Infantile Or Early Childhood, 1	IECEE1
DEE91	Infantile Or Early Childhood Epileptic Encephalopathy 1
Encephalopathy, Epileptic, Infantile Or Early Childhood, Type 1

Autosomal Dominant Non-Syndromic Intellectual Disability

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Osteomyelitis

Cardiomyopathy, Familial Hypertrophic, 10

Hypertrophic Cardiomyopathy 10	CMH10
Cardiomyopathy, Hypertrophic, Mid-Left Ventricular Chamber Type, 2	Cardiomyopathy, Hypertrophic, 10
Cardiomyopathy, Familial Hypertrophic 10	Familial Hypertrophic Cardiomyopathy With Mid-Left Ventricular Chamber Type 2
Mvc2	Cardiomyopathy, Hypertrophic, Familial, Type 10

Endocardium Disease

Septic Arthritis

Infectious Arthritis	Arthritis, Infectious
Arthritis Septic	Arthritis, Bacterial

Flying Phobia

Aerophobia

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Cataract 6, Multiple Types

Ctpp1	Cataract 6 Multiple Types
CTRCT6	Cataract, Posterior Polar, 1
Arcc2	Cataract, Age-Related Cortical, 2
Ctpa	Ctpp
Age Related Cortical Cataract 2	Posterior Polar Cataract 1
Posterior Polar Cataract, 1	Age-Related Cortical Cataract 2
Cataract Posterior Polar 1

Cornea Plana

Flat Cornea

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Benign Essential Hypertension

Infective Endocarditis

Bacterial Endocarditis	Endocarditis, Infective
Infectious Endocarditis	Endocarditis Infective

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Commensal Bacterial Infectious Disease

Impetigo

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11023	PPP3CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP3CA	MGD	MGI:107164
Macaca mulatta	PPP3CA	VGNC	VGNC:76382
Canis familiaris	PPP3CA	VGNC	VGNC:44918
Rattus norvegicus	PPP3CA	RGD	RGD:3382
Bos taurus	PPP3CA	VGNC	VGNC:33265
Felis catus	PPP3CA	VGNC	VGNC:69019
Others	PPP3CA	NCBI

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