Cacng8 - calcium voltage-gated channel auxiliary subunit gamma 8 Gene

Rattus norvegicus

Gene ID: 140729 | Gene type: protein coding

About Cacng8

Summary

Voltage-dependent calcium channels couple membrane depolarization in a number of cellular processes. These activities are regulated by distinct channels composed of the pore-forming alpha-1 subunit and the modulatory beta, alpha-2/delta and gamma subunits. The protein encoded by this gene represents one of the gamma subunits. It is an integral membrane protein that is thought to stabilize the Calcium Channel in an inactive (closed) state. This gene is located in a cluster with two similar gamma subunit-encoding genes on chromosome 1. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]

Cacng8 Products(1)

mRNA	Protein	Name
NM_080696.2	NP_542427.1	voltage-dependent calcium channel gamma-8 subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	12771129	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24418105	RGD
enables protein phosphatase 2B binding	IPI IPI: Inferred from physical interaction	24418105	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	12771129	RGD
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	17880894	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	24418105	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12771129	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	12771129	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	24418105	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-dependent calcium channel gamma-8 subunit

TARP gamma-8	calcium channel, voltage-dependent, gamma subunit 8
neuronal voltage-gated calcium channel gamma-8 subunit	transmembrane AMPAR regulatory protein gamma-8

Cacng8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Cacng8	Q8VHW5	PPP3CA	Homo sapiens	Q08209	Pull Down	24418105
Intra	Cacng8	Q8VHW5	Ppp3ca	Rattus norvegicus	P63329	Anti Bait CoIP	24418105
Intra	Cacng8	Q8VHW5	Ppp3ca	Rattus norvegicus	P63329	IF	24418105

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01815	CACNG8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacng8	NCBI	NCBI:59283

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