PPP3CB - protein phosphatase 3 catalytic subunit beta Gene

Homo sapiens

Also known as CNA2; CALNB; CALNA2; PP2Bbeta

Gene ID: 5532 | Gene type: protein coding

About PPP3CB

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,436,433-73,496,024 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues.

Summary

Enables several functions, including Calmodulin binding activity; calmodulin-dependent protein Phosphatase activity; and protein Phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of Calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PPP3CB Products(5)

mRNA	Protein	Name
NM_001142353.3	NP_001135825.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a
NM_001142354.3	NP_001135826.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c
NM_001289968.2	NP_001276897.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform d
NM_001289969.2	NP_001276898.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform e
NM_021132.4	NP_066955.1	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	8524402	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	2556704	GOA
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	19154138	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	11005320	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11005320	GOA
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	2556704	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	19154138	GOA
involved in calcineurin-mediated signaling	IMP IMP: Inferred from mutant phenotype	11005320	GOA
involved in positive regulation of lysosome organization	IDA IDA: Inferred from direct assay	25720963	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	25720963	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22688515	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	19154138	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcineurin complex	IDA IDA: Inferred from direct assay	8524402	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19154138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3CB Protein Structure

Metallophos

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

CAM-PRP catalytic subunit

PPP3CB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PPP3CB	P16298	Irak1	Mus musculus	Q99J34	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11024	PPP3CB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP3CB	VGNC	VGNC:82211
Mus musculus	PPP3CB	MGD	MGI:107163
Felis catus	PPP3CB	VGNC	VGNC:69020
Canis familiaris	PPP3CB	VGNC	VGNC:44919
Rattus norvegicus	PPP3CB	RGD	RGD:3383
Bos taurus	PPP3CB	VGNC	VGNC:33266

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