RNLS - renalase, FAD dependent amine oxidase Gene

Homo sapiens

Also known as C10orf59; RENALASE

Gene ID: 55328 | Gene type: protein coding

About RNLS

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,171,523-88,583,318 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

RNLS Products(2)

mRNA	Protein	Name
NM_001031709.3	NP_001026879.2	renalase isoform 1 precursor
NM_018363.4	NP_060833.1	renalase isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADH binding	IDA IDA: Inferred from direct assay	25531177	GOA
enables epinephrine binding	IDA IDA: Inferred from direct assay	23964689	GOA
enables monoamine oxidase activity	IMP IMP: Inferred from mutant phenotype	15841207	GOA
enables oxidoreductase activity, acting on NAD(P)H	IDA IDA: Inferred from direct assay	23964689	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25906147	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of blood pressure	IDA IDA: Inferred from direct assay	15841207	GOA
involved in negative regulation of heart rate	IDA IDA: Inferred from direct assay	15841207	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15841207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNLS Protein Structure

NAD_binding_8

Amino_oxidase

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

renalase

MAO-C

Related Diseases

Diseases

Alias

End Stage Renal Disease

End Stage Renal Failure	End-Stage Kidney Disease
Kidney Failure, Chronic	Chronic Kidney Disease Stage 5

Retinitis Pigmentosa 57

RP57	Pde6g-Related Retinitis Pigmentosa
Retinitis Pigmentosa, Type 57

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Chromosome 5q Deletion Syndrome

5q- Syndrome	Mar
Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality	Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic
5q Deletion Syndrome	5q Minus Syndrome
Refractory Macrocytic Anemia Due To 5q Deletion	Myelodysplastic Syndrome With Isolated Del
Macrocytic Anemia, Refractory, Due To 5q Deletion	5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion
5q Syndrome	Chromosome 5q Deletion
Myelodysplastic Syndrome With 5q Deletion	Myelodysplastic Syndrome With 5q Deletion Syndrome
Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic	5q-Syndrome
Chromosome 5, Trisomy 5q	Loss Of Chromosome 5q
5 Q- Syndrome

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12101	RNLS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNLS	VGNC	VGNC:82226
Mus musculus	RNLS	MGD	MGI:1915045
Canis familiaris	RNLS	VGNC	VGNC:45681
Bos taurus	RNLS	VGNC	VGNC:106901
Rattus norvegicus	RNLS	RGD	RGD:1309804
Others	RNLS	NCBI

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