ZGRF1 - zinc finger GRF-type containing 1 Gene

Homo sapiens

Also known as C4orf21

Gene ID: 55345 | Gene type: protein coding

About ZGRF1

This gene has 12 transcripts (splice variants) and 87 orthologues. Broad expression in bone marrow (RPKM 3.0), testis (RPKM 2.5) and 24 other tissues.

Summary

The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]

ZGRF1 Products(2)

mRNA	Protein	Name
NM_001350397.2	NP_001337326.1	protein ZGRF1 isoform 2
NM_018392.5	NP_060862.3	protein ZGRF1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-3' DNA helicase activity	IDA IDA: Inferred from direct assay	32640219	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32640219	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in recombinational repair	IDA IDA: Inferred from direct assay	32640219	GOA
involved in recombinational repair	IMP IMP: Inferred from mutant phenotype	32640219	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	32640219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein ZGRF1

GRF-type zinc finger domain-containing protein 1

ZGRF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	IF	34552057
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	Anti Tag CoIP	34552057
Intra	ZGRF1	Q86YA3	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	34552057
Intra	ZGRF1	Q86YA3	EXO1	Homo sapiens	Q9UQ84	Anti Bait CoIP	34552057
Intra	ZGRF1	Q86YA3	EXO1	Homo sapiens	Q9UQ84	Anti Tag CoIP	34552057

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Childhood Apraxia Of Speech

Cas	Articulatory Apraxia
Das	Developmental Apraxia Of Speech
Developmental Verbal Apraxia	Developmental Verbal Dyspraxia
Speech And Language Disorder With Orofacial Dyspraxia	Articulation Disorders, Developmental
Apraxia, Articulatory	Apraxia, Developmental Verbal

Scleral Staphyloma

Scleral Ectasia

Staphyloma Of Sclera

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16067	ZGRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZGRF1	RGD	RGD:1305834
Mus musculus	ZGRF1	MGD	MGI:1918893

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