2. Gene
  3. TMEM176A - transmembrane protein 176A Gene

TMEM176A - transmembrane protein 176A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GS188; MS4B1; HCA112

Gene ID: 55365 | Gene type: protein coding

About TMEM176A

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,800,769-150,805,118 (from NCBI)

This gene has 11 transcripts (splice variants), 86 orthologues and 1 paralogue. Broad expression in liver (RPKM 172.7), kidney (RPKM 114.0) and 15 other tissues.

Summary

Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM176A Products(1)

mRNA Protein Name
NM_018487.3 NP_060957.2 transmembrane protein 176A
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM176A Protein Structure

CD20

CD20: CD20-like family (57 - 214)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

transmembrane protein 176A

hepatocellular carcinoma-associated antigen 112

TMEM176A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM176A Q96HP8 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
TMEM176A Q96HP8 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Y2H Array
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM176A Q96HP8 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Y2H Array
32814053
Intra
TMEM176A Q96HP8 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
TMEM176A Q96HP8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14684 TMEM176A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMEM176A VGNC VGNC:66292
Rattus norvegicus TMEM176A RGD RGD:1310725
Mus musculus TMEM176A MGD MGI:1913308
Canis familiaris TMEM176A VGNC VGNC:47501
Bos taurus TMEM176A VGNC VGNC:36000
Macaca mulatta TMEM176A VGNC VGNC:81774