2. Gene
  3. MTIF3 - mitochondrial translational initiation factor 3 Gene

MTIF3 - mitochondrial translational initiation factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IF3mt

Gene ID: 219402 | Gene type: protein coding

About MTIF3

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:27,435,643-27,450,564 (from NCBI)

This gene has 12 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in fat (RPKM 26.6), testis (RPKM 20.2) and 25 other tissues.

Summary

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]

MTIF3 Products(4)

mRNA Protein Name
NM_001166261.2 NP_001159733.1 translation initiation factor IF-3, mitochondrial
NM_001166262.2 NP_001159734.1 translation initiation factor IF-3, mitochondrial
NM_001166263.2 NP_001159735.1 translation initiation factor IF-3, mitochondrial
NM_152912.5 NP_690876.3 translation initiation factor IF-3, mitochondrial

MTIF3 Protein Structure

IF3_N

IF3_N: Translation initiation factor IF-3, N-terminal domain (76 - 145)

IF3_C

IF3_C: Translation initiation factor IF-3, C-terminal domain (159 - 240)

  • 0
  • 100
  • 200
  • 278 a.a.
Protein Preferred Names Protein Names

translation initiation factor IF-3, mitochondrial

IF-3(Mt)

MTIF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MTIF3 Q9H2K0 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 TMEM109 Homo sapiens Q9BVC6
Y2H Array
32296183
Intra MTIF3 Q9H2K0 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 CTXN3 Homo sapiens Q4LDR2
Y2H Array
32296183
Intra MTIF3 Q9H2K0 FETUB Homo sapiens Q9UGM5
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra MTIF3 Q9H2K0 HSFX1 Homo sapiens Q9UBD0
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra MTIF3 Q9H2K0 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 39

COXPD39

Combined Oxidative Phosphorylation Defect Type 39

Gfm2-Related Combined Oxidative Phosphorylation Defect
Hallucinogen Abuse
Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3

COXPD3

Encephalomyopathy, Respiratory Failure, And Lactic Acidosis

Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis

Fatal Mitochondrial Disease Due To Coxpd3

Concentric Cardiomyopathy Hypotonia And Lactic Acidosis

Encephalomyopathy Respiratory Failure And Lactic Acidosis

Encephalomyopathy With Respiratory Failure And Lactic Acidosis

Combined Oxidative Phosphorylation Deficiency, Type 3
Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1

COXPD1

Early Fatal Progressive Hepatoencephalopathy

Hepatoencephalopathy Due To Coxpd1

Combined Oxidative Phosphorylation Deficiency, Type 1

Hepatoencephalopathy, Early Fatal Progressive

Hepatoencephalopathy Early Fatal Progressive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08782 MTIF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MTIF3 RGD RGD:1592673
Macaca mulatta MTIF3 VGNC VGNC:75040
Bos taurus MTIF3 VGNC VGNC:31734
Mus musculus MTIF3 MGD MGI:1923616
Canis familiaris MTIF3 VGNC VGNC:43476
Felis catus MTIF3 VGNC VGNC:63651