PPY - pancreatic polypeptide Gene

Homo sapiens

Also known as PP; PNP

Gene ID: 5539 | Gene type: protein coding

About PPY

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,940,804-43,944,215 (from NCBI)

This gene has 6 transcripts (splice variants), 90 orthologues and 2 paralogues. Biased expression in pancreas (RPKM 7.7), colon (RPKM 0.9) and 1 other tissue.

Summary

This gene encodes a member of the neuropeptide Y (NPY) family of Peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PPY Products(2)

mRNA	Protein	Name
NM_001319209.2	NP_001306138.1	pancreatic prohormone isoform 2 precursor
NM_002722.5	NP_002713.1	pancreatic prohormone isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	7493937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPY Protein Structure

Hormone_3

0
95 a.a.

Protein Preferred Names

Protein Names

pancreatic prohormone

pancreatic polypeptide Y

Recombinant PPY Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71062	PPY Protein, Human (HEK293, His)	P01298 (A30-R88)	≥95%

Related Diseases

Diseases

Alias

Non-Functioning Pancreatic Endocrine Tumor

Non Functioning Pancreatic Endocrine Tumor	Non-Functioning Epts
Non-Functioning Endocrine Pancreatic Tumors

Auditory System Cancer

Ear Neoplasms

Middle Ear Adenocarcinoma

Adenocarcinoma Of Middle Ear

Adenocarcinoma Of The Middle Ear

Middle Ear Adenoma

Adenoma Of Middle Ear

Adenoma Of The Middle Ear

Auditory System Benign Neoplasm

Sensory Organ Benign Neoplasm

Pancreatic Somatostatinoma

Pancreatic Delta Cell Somatostatin Producing Neoplasm

Pancreatic Somatostatin Cell Tumor

Pancreatic Cholera

Excessive Vasoactive Intestinal Peptide Secretion	Pancreatic Wdha Syndrome
Verner-Morrison Syndrome

Ceruminoma

Ceruminous Adenoma

External Auditory Canal Ceruminous Adenoma

Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor	Somatosatinoma Of Jejunum
Jejunal Somatostatin-Producing Neuroendocrine Tumor

Endocrine Pancreas Disease

Disorder Of Endocrine Pancreas

Duodenal Gastrinoma

Duodenal G-Cell Gastrin Producing Tumor	Gastrinoma Of Duodenum
Malignant Duodenal Gastrinoma	Duodenal Gastrin-Producing Neuroendocrine Tumor

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Pancreatic Gastrinoma

Pancreatic G-Cell Tumor

Duodenal Somatostatinoma

Duodenal Delta Cell Somatostatin Producing Tumor

Duodenal Somatostatin-Producing Neuroendocrine Tumor

Diabetic Autonomic Neuropathy

Diabetic Neuropathies

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Middle Ear Carcinoma

Carcinoma Of Middle Ear

Carcinoma Of The Middle Ear

Ceruminous Adenocarcinoma

Vipoma

Wdha Syndrome	Pancreatic Cholera
Pancreatic Vipoma	Verner-Morrison Syndrome
Diarrheogenic Islet Cell Tumor	Vip-Secreting Tumor
Malignant Vasoactive Intestinal Peptide-Secreting Tumor	Vasoactive Intestinal Peptide-Secreting Tumor
Vip- Secreting Tumor	Vipoma, Malignant
Vipoma Syndrome	Watery Diarrhea Syndrome
Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome	Vasoactive Intestinal Peptide Tumor
Vasoactive Intestinal Peptide-Producing Tumor	Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome
Malignant Vipoma

Acute Hemorrhagic Pancreatitis

Pancreatitis, Acute Hemorrhagic

Mahvash Disease

Gcgr-Related Hyperglucagonemia	MVAH
Alpha-Cell Hyperplasia With Glucagonemia	Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor
Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor

Somatostatinoma

Somatostatin Cell Neoplasm	Somatostatin Cell Tumour
Ampullary Somatostatinoma	Carcinoid Somatostatinoma
Malignant Islet Cell Tumor	Somatomedin-Secreting Carcinoid
Somatostatin-Secreting Pancreatic Neoplasm	Pancreatic Somatostatinoma
Pancreatic Endocrine Carcinoma

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor	Neuroendocrine Tumor Of Pancreas
Pnet	Pancreatic Net
Pancreatic Endocrine Tumor	Well-Differentiated Nen Of Pancreas
Well-Differentiated Neuroendocrine Neoplasm Of Pancreas	Well-Differentiated Pancreatic Nen
Well-Differentiated Pancreatic Neuroendocrine Neoplasm	Endocrine Pancreas Cancer
Islet Cell Neoplasm	Islet Cell Tumour
Malignant Pancreatic Endocrine Tumor	Malignant Pancreatic Endocrine Tumour
Malignant Tumor Of Endocrine Pancreas	Malignant Tumour Of Endocrine Pancreas
Pancreatic Endocrine Neoplasm	Pancreatic Neuroendocrine Neoplasm
Adenoma, Islet Cell	Well Differentiated Pancreatic Endocrine Tumor
Malignant Neoplasm Of Endocrine Pancreas	Pancreatic Endocrine Carcinoma

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Pancreatic Endocrine Carcinoma

Carcinoma Of Endocrine Pancreas	Islet Cell Carcinoma
Malignant Neoplasm Of Islets Of Langerhans	Pancreatic Neuroendocrine Carcinoma
Carcinoma Islet Cell	Carcinoma, Islet Cell

Functional Gastric Disease

Partington Syndrome

X-Linked Reticulate Pigmentary Disorder	PRTS
Partington X-Linked Mental Retardation Syndrome	Mrxs1
Mrx36	Intellectual Developmental Disorder, X-Linked, Syndromic 1
Partington Disease	Pdr
Partington-Mulley Syndrome	Russell-Silver Syndrome, X-Linked
Mental Retardation, X-Linked, Syndromic 1	Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures
Mental Retardation, X-Linked 36	X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations
X-Linked Russell-Silver Syndrome	Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome
Intellectual Disability, X-Linked, Syndromic 1	Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures
Partington X-Linked Intellectual Disability Syndrome	X-Linked Intellectual Deficit-Dystonia-Dysarthria
X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures	Familial Cutaneous Amyloidosis
X-Linked Cutaneous Amyloidosis	Xlpdr
X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome	Pigmentary Disorder, Reticulate, With Systemic Manifestations

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Space Motion Sickness

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction	Autonomic Nervous System Disorders
Autonomic Nervous System Disorder	Autonomic Nervous System Diseases
Abnormality Of The Autonomic Nervous System

Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Endometrial Small Cell Carcinoma

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Peptic Ulcer Disease

Peptic Ulcer	Acute Peptic Ulcer With Hemorrhage
Acute Peptic Ulcer With Hemorrhage And Perforation	Acute Peptic Ulcer Without Hemorrhage And Without Perforation

Duodenum Cancer

Duodenal Cancer	Duodenal Neoplasms
Cancer Of Duodenum	Duodenal Neoplasm
Duodenal Carcinoma	Cancer, Duodenal
Malignant Neoplasm Of Duodenum

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Duodenum Disease

Duodenal Diseases	Duodenal Disease
Duodenum Disorder

Gastrointestinal System Benign Neoplasm

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Diabetes Mellitus

Diabetes

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12083	PPY-A	Inhibitor	/	Unkown
HY-RS11042	PPY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W013430	4-Amino-3-hydroxynaphthalene-1-sulfonic acid		/	Unkown
HY-W007596	Tris(2-phenylpyridinato-C2,N)iridium(III)		≥98.0%	Unkown
HY-W034041	Ir(p-F-ppy)3		/	Unkown
HY-W035599	Ir[p-F(t-Bu)-ppy]3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPY	MGD	MGI:97753
Macaca mulatta	PPY	VGNC	VGNC:76387
Felis catus	PPY	VGNC	VGNC:69026
Bos taurus	PPY	VGNC	VGNC:55864
Canis familiaris	PPY	VGNC	VGNC:44933
Rattus norvegicus	PPY	RGD	RGD:3385
Others	PPY	NCBI