PRB3 - proline rich protein BstNI subfamily 3 Gene

Homo sapiens

Also known as G1; PRG

Gene ID: 5544 | Gene type: protein coding

About PRB3

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,265,914-11,269,707 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 4 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 9550.6).

Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of Polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

PRB3 Products(2)

mRNA	Protein	Name
NM_001394862.1	NP_001381791.1	basic salivary proline-rich protein 3 isoform 2 precursor
NM_006249.5	NP_006240.4	basic salivary proline-rich protein 3 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRB3 Protein Structure

Pro-rich

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

basic salivary proline-rich protein 3

BstNI type basic salivary proline-rich protein 3

PRB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRB3	Q04118	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
Intra	PRB3	Q04118	TBRG4	Homo sapiens	Q969Z0	Validated Y2H	32296183
Intra	PRB3	Q04118	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	PRB3	Q04118	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	PRB3	Q04118	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	PRB3	Q04118	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11053	PRB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRB3	RGD	RGD:620386

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