TBRG4 - transforming growth factor beta regulator 4 Gene

Homo sapiens

Also known as CPR2; FASTKD4

Gene ID: 9238 | Gene type: protein coding

About TBRG4

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:45,100,100-45,111,697 (from NCBI)

This gene has 17 transcripts (splice variants), 195 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 18.2), duodenum (RPKM 14.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

TBRG4 Products(4)

mRNA	Protein	Name
NM_001261834.2	NP_001248763.1	FAST kinase domain-containing protein 4 isoform 3
NM_004749.4	NP_004740.2	FAST kinase domain-containing protein 4 isoform 1
NM_030900.4	NP_112162.1	FAST kinase domain-containing protein 4 isoform 2
NM_199122.3	NP_954573.1	FAST kinase domain-containing protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	28335001	GOA
involved in mitochondrial mRNA processing	IMP IMP: Inferred from mutant phenotype	28335001	GOA
involved in regulation of mitochondrial mRNA stability	IMP IMP: Inferred from mutant phenotype	28335001	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	28335001	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20869947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBRG4 Protein Structure

FAST_1

FAST_2

RAP

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

FAST kinase domain-containing protein 4

FAST kinase domains 4

TBRG4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TBRG4	Q969Z0	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	TBRG4	Q969Z0	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	TBRG4	Q969Z0	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	TBRG4	Q969Z0	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	TBRG4	Q969Z0	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	CDR2L	Homo sapiens	Q86X02	Y2H Array	32296183
Intra	TBRG4	Q969Z0	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	PRB3	Homo sapiens	Q04118	Y2H Array	32296183
Intra	TBRG4	Q969Z0	PRB3	Homo sapiens	Q04118	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TBRG4	Q969Z0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	TBRG4	Q969Z0	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TBRG4	Q969Z0	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	TBRG4	Q969Z0	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	TBRG4	Q969Z0	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	TBRG4	Q969Z0	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	TBRG4	Q969Z0	GPRASP2	Homo sapiens	Q96D09	Validated Y2H	32296183
Intra	TBRG4	Q969Z0	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	TBRG4	Q969Z0	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	TBRG4	Q969Z0	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	TBRG4	Q969Z0	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	TBRG4	Q969Z0	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	TBRG4	Q969Z0	MAL2	Homo sapiens	Q969L2	Validated Y2H	25416956
Intra	TBRG4	Q969Z0	MAL2	Homo sapiens	Q969L2	Y2H Array	25416956
Intra	TBRG4	Q969Z0	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183
Intra	TBRG4	Q969Z0	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14269	TBRG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TBRG4	VGNC	VGNC:47168
Rattus norvegicus	TBRG4	RGD	RGD:1309737
Bos taurus	TBRG4	VGNC	VGNC:35664
Mus musculus	TBRG4	MGD	MGI:1100868
Felis catus	TBRG4	VGNC	VGNC:66000
Macaca mulatta	TBRG4	VGNC	VGNC:78151

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