HES6 - hes family bHLH transcription factor 6 Gene

Homo sapiens

Also known as HES-6; bHLHb41; bHLHc23; C-HAIRY1

Gene ID: 55502 | Gene type: protein coding

About HES6

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,238,267-238,240,038 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 12 paralogues. Biased expression in brain (RPKM 23.5), colon (RPKM 8.2) and 12 other tissues.

Summary

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

HES6 Products(3)

mRNA	Protein	Name
NM_001142853.3	NP_001136325.1	transcription cofactor HES-6 isoform b
NM_001282434.2	NP_001269363.1	transcription cofactor HES-6 isoform c
NM_018645.6	NP_061115.2	transcription cofactor HES-6 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES6 Protein Structure

HLH

Hairy_orange

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

transcription cofactor HES-6

class B basic helix-loop-helix protein 41

HES6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HES6	Q96HZ4	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	HES6	Q96HZ4	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	HES6	Q96HZ4	TLE1	Homo sapiens	Q04724	Anti Tag CoIP	33961781
Intra	HES6	Q96HZ4	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	HES6	Q96HZ4	RAB2A	Homo sapiens	P61019	Y2H Array	32296183
Intra	HES6	Q96HZ4	RAB2A	Homo sapiens	P61019	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06139	HES6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HES6	VGNC	VGNC:99366
Felis catus	HES6	VGNC	VGNC:80228
Canis familiaris	HES6	VGNC	VGNC:59081
Rattus norvegicus	HES6	RGD	RGD:1312047
Bos taurus	HES6	VGNC	VGNC:29823
Mus musculus	HES6	MGD	MGI:1859852

Name
Email *

	Sorry, but the email address you supplied was invalid.